Combination of Hyperfractionated Radiotherapy With Immunotherapy in Massive Tumors

Inclusion Criteria:

1. Age ≥18 years old, male or female；
2. ECOG score will be 0 - 2；
3. The life expectancy will be longer than 12 weeks；
4. Patients with non-small cell lung cancer, soft tissue sarcoma or urothelial carcinoma were confirmed by histopathology；
5. Contain at least 1 measurable lesion with the largest long diameter ≥ 5cm;
6. The main organ functions are normal, and the results of laboratory test must be met the following criteria: Absolute neutrophil count（ANC）: more than 1.5 × 109/L; Platelets（PLT）: more than 75× 109/L; Total Bilirubin（TBil）：less than the upper normal limit (ULN); ALT and AST：less than 2.5 folds of the upper normal limit (ULN)，if there is liver metastasis, ALT and AST must be less than 5 folds of the upper normal limit (ULN) ; Urea Nitrogen (BUN): less than 2.5×ULN；Endogenous creatinine clearance ≥45 ml/min (Cockcroft-Gault formula);
7. Female subjects of childbearing age must undergo a serum pregnancy test within 3 days before starting the study drug, and the result is negative.Female and male subjects should take effective contraceptive measures from the beginning of treatment to within 3 months after the end of treatment;
8. Agreeing to participate in this study and signing a written informed consent.

Exclusion Criteria:

1. Central nervous system metastasis (including brain metastasis, meningeal metastasis, etc.);
2. Other immunosuppressive drugs used within 14 days before before study drug administration, excluding nasal sprays and inhaled corticosteroids or physiological doses of systemic steroids (ie not more than 10 mg/day of prednisolone or Other corticosteroids of equivalent pharmacological physiological dose);
3. Hypertension and unable to be controlled within normal level following treatment of anti-hypertension agents: systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥ 90 mmHg;
4. Clinically significant cardiovascular diseases：Myocardial ischemia or myocardial infarction above grade II, ventricular arrhythmia which poorly controlled，QTc\>450ms（male）/QTc\>470ms (female)；Congestive heart failure (New York heart association (NYHA) class is Ⅲ～Ⅳ)；or cardiac color Doppler ultrasound examination revealed that the left ventricular ejection fraction (LVEF) \<50%;
5. Accompanied by uncontrolled pleural effusion, pericardial effusion, or ascites that requires repeated drainage;
6. Patients with any active autoimmune disease or history of autoimmune disease, including but not limited to the following: hepatitis, pneumonitis, uveitis, colitis (inflammatory bowel disease), hypophysitis, vasculitis, nephritis, hyperthyroidism, and hypothyroidism;
7. Asthma that requires intermittent use of bronchodilators or other medical intervention should be excluded（Asthma has been completely relieved in childhood, and those without any intervention after adulthood can be included);
8. Coagulation abnormalities (INR\>1.5、PT\>ULN+4s、APTT \>1.5 ULN）, with bleeding tendency or are receiving thrombolytic or anticoagulant therapy;
9. Proteinuria ≥ (++) and 24 hours total urine protein \> 1.0 g;
10. Received major surgery or suffered severe traumatic injury, fracture or ulcer within 4 weeks before enrollment;
11. Severe infections (such as intravenous infusion of antibiotics, antifungal or antiviral drugs) within 4 weeks before the first administration, or unexplained fever\> 38.5°C during the screening period/before the first administration;
12. Clinically significant hemoptysis or more than half a teaspoon (2.5ml) of hemoptysis per day occurred within 2 months before enrollment; or Clinically significant bleeding symptoms or tendency, such as gastrointestinal bleeding, hemorrhagic Gastric ulcer, fecal occult blood≥++ at baseline, or vasculitis, etc.;
13. Arterial/venous thrombosis events occurred in the 12 months before enrollment, such as cerebrovascular accidents (including temporary ischemic attacks, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, and pulmonary embolism;
14. History of immunodeficiency or human immunodeficiency virus (HIV) infection, HBV DNA\>500 IU/ml, HCV RNA\>1000copies/ml, HBsAg+ and anti-HCV+；
15. Patients with a clear history of allergies may be potentially allergic or intolerant to camrelizumab and apatinib;
16. Patients who have a history of psychotropic drug abuse and cannot be quit or have mental disorders;
17. Other condition, illness, psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or stereotactic radiotherapy administration, or may interfere with the interpretation of study results and in the judgment of the investigator would make the patient inappropriate for entry into this study.