Clinical trial · Interventional
Semi-sitting Versus Supine Position in Endoscopic Skull Base Surgery
Semi-sitting Versus Supine Position in Endoscopic Skull Base Surgery (PosESS-Study) - Study Protocol for a Randomized-controlled Single-blinded Superiority Trial
NCT04584866CI-TRIAL-00089070PosESScompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is to prospectively compare the standard supine (control group) and the semi-sitting position (head elevation of 30°; intervention group) in endoscopic endonasal pituitary surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Adenoma | Pituitary Neuroendocrine Tumor | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endonasal endoscopic pituitary surgery in semi-sitting position | Procedure | — | UNRESOLVED |
| Endonasal endoscopic pituitary surgery in supine position | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Study Intervention
- description
- Endonasal endoscopic pituitary surgery in semi-sitting position
- interventionNames
- Procedure: Endonasal endoscopic pituitary surgery in semi-sitting position
- type
- ACTIVE_COMPARATOR
- label
- Control Intervention
- description
- Endonasal endoscopic pituitary surgery in supine position
- interventionNames
- Procedure: Endonasal endoscopic pituitary surgery in supine position
Primary outcomes (2)
- measure
- Intraoperative blood loss
- timeFrame
- Intraoperative
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with a presumed pituitary pathologies who are suitable for endoscopic endonasal surgical resection Exclusion Criteria: * Patients with known hemorrhagic or thrombophilic disorders * Patients with conditions associated with high central venous pressure: congestive heart failure, pulmonary hypertension, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pregnancy * Patients with poor cardiopulmonary condition (unable to perform 4 metabolic equivalents without stopping (climb a flight of stairs))
References
Publications (0)
Data not yet available
No reference posted for this study.