Clinical trial · Interventional
Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer (Including Metastatic Cancer) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
| Pulmonary Infection | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| iloprost inhalation | Drug | — | UNRESOLVED |
| normal saline inhalation | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- placebo
- description
- normal saline inhalation group
- interventionNames
- Drug: normal saline inhalation
- type
- EXPERIMENTAL
- label
- iloprost group
- description
- iloprost inhalation group
- interventionNames
- Drug: iloprost inhalation
Primary outcomes (3)
- measure
- Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
- timeFrame
- 20 minutes after iloprost inhalation (T2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. scheduled for VATS lobectomy 2. 40 \< age \< 80 3. American Society of Anaesthesiologists(ASA) physical status classification I\~III 4. BMI \> 30 kg /m2 Exclusion Criteria: 1. American Society of Anaesthesiologists(ASA) physical status classification IV or more 2. NYHA class III\~IV 3. Severe obstructive lung disease and/or restrictive lung disease patients 4. patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure) 5. arrhythmia 6. pregnant women 7. pulmonary edema or pulmonary arterial hypertension 8. cerebrovascular disease 9. unstable angina or myocardial infarction within 6 months 10. patients with allergic reaction at iloprost
References
Publications (0)
Data not yet available