Clinical trial · Observational
Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer
Preservation of Ovaries in Endometrial Malignancies: GYN POEM Trial
NCT04569773CI-TRIAL-00122933active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Decision Regret Scale | Behavioral | — | UNRESOLVED |
| Impact of Event Scale-Revised | Behavioral | — | UNRESOLVED |
| Reproductive Concerns Scale | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Participants undergoing surgery for clinical
- description
- Participants will be undergoing surgery for clinical stage I endometrioid endometrial cancer
- interventionNames
- Behavioral: Impact of Event Scale-Revised
- Behavioral: Reproductive Concerns Scale
- Behavioral: Decision Regret Scale
Primary outcomes (1)
- measure
- Examine the decision-making process of patients who choose to undergo or not undergo ovarian-sparing surgical treatment of endometrial cancer
- timeFrame
- Up to 12 months post-operatively
- description
- Examine the decision-making process of patients who choose to undergo or not undergo ovarian-sparing surgical treatment of endometrial cancer to identify influencing factors-in particular, cancer-related psychological distress and reproductive concerns-and any potential decisional regrets following surgical intervention.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged ≥ 18 and ≤ 50 years * Premenopausal * Endometrioid histological diagnosis * Scheduled for surgical intervention at MSKCC * FIGO grade 1-2, clinical stage I * Disease confined to uterus, no clear evidence of deep (≥50%) myoinvasion on imaging (MRI preferred, ultrasound optional) * Normal ovaries on preoperative imaging * Able to provide informed consent * English-speaking Exclusion Criteria: * Known Lynch syndrome * Prior bilateral oophorectomy * Personal history of hormone receptor-positive breast carcinoma * Increased risk of ovarian cancer identified on the basis of family or personal history * Women currently on hormonal contraception, letrozole, or tamoxifen may not opt-in to AMH * Women who recently underwent ovarian stimulation within the past 3 months may not opt-in to AMH * Women who have pituitary dysfunction (or any pituitary disorders) may not opt-in to AMH * Women who completed chemotherapy within \<12 months may not opt-in to AMH
References
Publications (0)
Data not yet available
No reference posted for this study.