Clinical trial · Observational
Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy
Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy: Focus on Health-Related Quality of Life and Cognition
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): PRMC closed for low accrual
Summary
Brief summary (as posted)
This study represents a survivorship protocol that focuses on cognition and health-related quality of life (HRQoL) in cancer patients that have received prior brain irradiation. The primary purpose of this study is to assess the feasibility of using a digital symptom tracking application focused on HRQoL and cognition in cancer survivors who received brain irradiation.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Metastases, Adult | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Primary Brain Tumor | Primary Brain Tumor | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Noona® application | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Noona® mobile healthcare application
- description
- All patients will be instructed to report pre-defined, non-life-threatening cognitive symptoms as often as relevant through the Noona® application for 17 weeks.
- interventionNames
- Other: Noona® application
Primary outcomes (1)
- measure
- Feasibility of using a digital symptom tracking application focused on HRQoL and cognition in cancer survivors who received brain irradiation
- timeFrame
- Baseline, 15 weeks
- description
- The percentage of patients returning for their Week 15 clinic appointment who initiate PROMIS and ESAS questionnaires via the mobile application at Week 14
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Cancer survivors who received cranial irradiation including, but not limited to, primary brain tumor, brain metastases, lung cancer receiving prophylactic brain irradiation, long-term survivors of pediatric cancers 2. Initial radiation must have been completed more than 6 months prior to enrollment. Acceptable radiation therapies include fractionated partial brain irradiation, whole brain irradiation, or stereotactic radiosurgery (for any modality at least a total cumulative dose of 20 Gy) of at least 20 Gy 3. Age ≥ 18 years at the time of entry into the study 4. Karnofsky performance score (KPS) ≥ 70 or Eastern Cooperative Oncology Group (ECOG) grade ≤ 2 5. No imaging evidence of disease progression within 4 months of enrollment 6. Life expectancy \> 6 months per treating neuro-oncology providers 7. Access to a smartphone, tablet, or computer with capability to utilize the mobile symptom-tracking application 8. Subject must be fluent in English Exclusion Criteria: 1\. Active psychiatric illness
References
Publications (0)
Data not yet available