Clinical trial · Interventional
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
Effects of the Application of a High-flow System Nasal Cannulas (Opti-Flow) Post General Anesthesia Versus Conventional Oxygen Therapy for Post-operative Hypoxemia After Gynecological Oncology Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The secondary objectives are to investigate the occurrence and entity of lung atelectasis, to evaluate diaphragmatic function and respiratory discomfort, and to evaluate the incidence of respiratory complications after seven days in the two groups. Patients will be randomized into two groups: HFNC and Control. The patients will be studied with preoperative lung and diaphragmatic ultrasound. Standard general anesthesia will be administered in the two groups. Ultrasound will be performed at arrival in the recovery room (RR) and before discharge from the RR. In the HFNC group, high-flow O2 will be administered; in the control group standard O2 therapy with Venturi mask will be administered. Arterial blood gas analysis upon arrival in the RR and after two hours of O2 therapy in both groups will be checked. The incidence of post-operative respiratory complications will be monitored in the seven days following surgery.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia | — | UNRESOLVED | — |
| Gynecologic Cancer | Malignant Female Reproductive System Neoplasm | ALIAS | 0.90 |
| Hypoxemia | — | UNRESOLVED | — |
| Postoperative Complications | — | UNRESOLVED | — |
| Pulmonary Atelectasis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HFNC - Airvo 2 | Device | — | UNRESOLVED |
| Oxygen | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Control group
- description
- Oxygen delivered by Venturi Mask
- interventionNames
- Other: Oxygen
- type
- EXPERIMENTAL
- label
- HFNC - high flow nasal cannulae
- description
- Oxygen delivered by high flow nasal cannula (HFNC) 60 l/min
- interventionNames
- Device: HFNC - Airvo 2
Primary outcomes (1)
- measure
- PaO2/FiO2 ratio
- timeFrame
- At arrival in recovery room (10 min after extubation) and before discharge from recovery room (after 2 hours from arrival in recovery room).
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients scheduled for major gynecologic oncologic surgery (surgery duration \> 2 hours). Exclusion Criteria: * patient's refusal to participate to the study * pregnancy * mechanical ventilation in the 2 weeks before surgery * BMI\>35
References
Publications (1)
- DERIVEDFrassanito L, Grieco DL, Zanfini BA, Catarci S, Rosa T, Settanni D, Fedele C, Scambia G, Draisci G, Antonelli M. Effect of a pre-emptive 2-hour session of high-flow nasal oxygen on postoperative oxygenation after major gynaecologic surgery: a randomised clinical trial. Br J Anaesth. 2023 Oct;131(4):775-785. doi: 10.1016/j.bja.2023.07.002. Epub 2023 Aug 4. PMID 37543437