Clinical trial · Interventional
Perioperative Cognitive Training in Thoracic Surgery
Perioperative Cognitive Flexibility Training for the Prevention of Persistent Pain After Thoracic Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Trial not funded.
Summary
Brief summary (as posted)
More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use. The proposed project aims to determine whether a prospective, randomized, controlled study of smartphone-based perioperative cognitive flexibility training will reduce the incidence of PPSP in high-risk individuals undergoing thoracic surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Function Abnormal | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Pain, Postoperative | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| COFLEX neurocognitive training | Behavioral | — | UNRESOLVED |
| Crossword puzzles | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- COFLEX training
- description
- Neurocognitive training, delivered via a mobile device app
- interventionNames
- Behavioral: COFLEX neurocognitive training
- type
- ACTIVE_COMPARATOR
- label
- Crossword group
- description
- Access to crossword puzzles via a mobile device app
- interventionNames
- Behavioral: Crossword puzzles
Primary outcomes (1)
- measure
- The presence of clinically meaningful persistent post-surgical pain 3 months after surgery
- timeFrame
- 3 months after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adults age 18 to 75 undergoing thoracic surgery * Access to an active email account * Score \<50th percentile on Color Word Matching Stroop Test (CWMST) normalized T-score Exclusion Criteria: * Unable to complete cognitive testing * Color blindness assessed via self-report * Participants who do not speak or read English The inclusion criteria for the observational cohort will be the same, with the exception of Score ≥50th percentile on Color Word Matching Stroop Test (CWMST) normalized T-score.
References
Publications (3)
- BACKGROUNDKehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006 May 13;367(9522):1618-25. doi: 10.1016/S0140-6736(06)68700-X. PMID 16698416
- BACKGROUNDSchug SA, Lavand'homme P, Barke A, Korwisi B, Rief W, Treede RD; IASP Taskforce for the Classification of Chronic Pain. The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain. Pain. 2019 Jan;160(1):45-52. doi: 10.1097/j.pain.0000000000001413. PMID 30586070
- BACKGROUNDSmith BH, Torrance N. Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep. 2012 Jun;16(3):191-8. doi: 10.1007/s11916-012-0256-0. PMID 22395856