Clinical trial · Interventional
Phenol and Silver Nitrate Application in Pilonidal Sinus
Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pilonidal sinus is a disease that affects the young population. Wound healing is a problem after surgical interventions Especially wound healing brings minimally invasive interventions to the fore. In this study we will administer two types of irritating agent for pilonidal sinus disesase. One of them is phenol and second one is silver nitrate solution. And not routinely used for pilonidal sinus disease. The data about availeble in pubmed and google scholar is limited focused on silver nitrate The goal of the study is to compare the silver nitrate and phenol application
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pilonidal Sinus of Natal Cleft | — | UNRESOLVED | — |
| Pilonidal Sinus Without Abscess | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Phenol | Drug | — | UNRESOLVED |
| Silver Nitrate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Phenolisation
- description
- Surgical pit excision and phenolisation of sinus tract
- interventionNames
- Drug: Phenol
- type
- ACTIVE_COMPARATOR
- label
- Silver Nitrate Irrigation
- description
- Surgical pit excision and silver nitrate irrigation of sinus tract
- interventionNames
- Drug: Silver Nitrate
Primary outcomes (1)
- measure
- Healing of the pilonidal sinus disease
- timeFrame
- 8 week
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 years old * Patients who applied to general surgery outpatient clinic for chronic sacrococcygeal pilonidal sinus * Patients with written informed voluntary consent forms. Exclusion Criteria: * BMI \> 35 kg/m² * Recurrent cases * Active abscess formation * Patients with hydradenitis suppurativa and skin lesions in the perianal region * Patients with accompanying anal fistula, anal conduloma and perianal involvement of Crohn's disease * Immunosuppressive patients (HIV +, organ transplantation, patients receiving immunosuppressive therapy) * Complicated cases (have more than 3 orifice) * Patients with known allergic sensitivity to one of the silver nitrate, phenol, nitrofurazone and prilocaine substances
References
Publications (6)
- BACKGROUNDBrazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, Usherwood T, Westlake L. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992 Jul 18;305(6846):160-4. doi: 10.1136/bmj.305.6846.160. PMID 1285753
- BACKGROUNDChan AW, Tetzlaff JM, Gotzsche PC, Altman DG, Mann H, Berlin JA, Dickersin K, Hrobjartsson A, Schulz KF, Parulekar WR, Krleza-Jeric K, Laupacis A, Moher D. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013 Jan 8;346:e7586. doi: 10.1136/bmj.e7586. PMID 23303884
- RESULTPronk AA, Smakman N, Furnee EJB. Short-term outcomes of radical excision vs. phenolisation of the sinus tract in primary sacrococcygeal pilonidal sinus disease: a randomized-controlled trial. Tech Coloproctol. 2019 Jul;23(7):665-673. doi: 10.1007/s10151-019-02030-w. Epub 2019 Jul 5. PMID 31278458
- RESULTAttaallah W, Tuney D, Gulluoglu BM, Ugurlu MU, Gunal O, Yegen C. Should we consider topical silver nitrate irrigation as a definitive nonsurgical treatment for perianal fistula? Dis Colon Rectum. 2014 Jul;57(7):882-7. doi: 10.1097/DCR.0000000000000143. PMID 24901690
- RESULTKayaalp C, Aydin C. Review of phenol treatment in sacrococcygeal pilonidal disease. Tech Coloproctol. 2009 Sep;13(3):189-93. doi: 10.1007/s10151-009-0519-x. Epub 2009 Aug 5. PMID 19655223
- RESULTEmiroglu M, Karaali C, Esin H, Akpinar G, Aydin C. Treatment of pilonidal disease by phenol application. Turk J Surg. 2017 Mar 1;33(1):5-9. doi: 10.5152/UCD.2016.3532. eCollection 2017. PMID 28589180