Clinical trial · Observational
Selective Versus Nonselective Alpha-blockade Prior to Pheochromocytoma Resection - Systematic Review and Meta-analysis
NCT04557072CI-TRIAL-00052343completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Our aim was to systematically evaluate the current data on the efficacy of pretreatment with either selective or nonselective alpha-blockade on the hemodynamic instability and morbidity during pheochromocytoma resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pheochromocytoma | Adrenal Gland Pheochromocytoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-selective alpha-1-antagonist | Drug | — | UNRESOLVED |
| Selective alpha-1-antagonist | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- The selective alpha-blockade group
- description
- Patients treated with selective alpha-blockade before pheochromocytoma surgery
- interventionNames
- Drug: Selective alpha-1-antagonist
- label
- The non-selective alpha-blockade group
- description
- Patients treated with non-selective alpha-blockade before pheochromocytoma surgery
- interventionNames
- Drug: Non-selective alpha-1-antagonist
Primary outcomes (1)
- measure
- Intraoperative maximum systolic blood pressure (mm Hg)
- timeFrame
- intraoperative
Secondary outcomes (13)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients who received selective or nonselective alpha-blockade prior to pheochromocytoma resection Exclusion Criteria: * Patients who did not receive alpha blockade * Patients not undergoing surgery * No comparison for selective and non-selective pretreatment in the study * Studies without primary or sufficient data (reviews, guidelines, meeting abstracts, letters), * Studies reported in a language other than English
References
Publications (0)
Data not yet available
No reference posted for this study.