HepATocellular Cancer Hcv Therapy Study

Inclusion Criteria:

* Hepatitis C diagnosed as the HCV RNA (≥ 10,000 IU/mL in peripheral blood) at the time of screening
* Genotype inclusions
* Have documented chronic HCV GT1 or GT4, (with no evidence of nontypeable or mixed genotype) infection
* HCC diagnosed on the basis of histology or according to AASLD radiological criteria,
* Written informed consent granted prior to initiation of any study-specific screening procedures
* Patients aged 18 to 70 years-old;
* Child-Pugh ≤≤ A6
* BCLC stage 0, A HCC or no detectable HCC in a patient who has undergone a curative form of treatment (liver transplantation, surgical resection of local ablative therapy with curative intent) OR BCLC-B disease but clinically stable with non-evidence of disease progression as demonstrated by either Triphasic CT or contrast MRI at least 3 months after the last HCC treatment.

Exclusion Criteria:

* Enrolment in other investigation / experimental therapies

  * Prior or current use of Sorafenib or other systemic chemotherapy
  * Life expectancy \< 12 months (unless transplantation eligible)
  * Unable to provide informed consent
  * Previous or concurrent cancer that is distinct from HCC in primary site or histology, EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, and superficial bladder tumors (Ta, Tis \& T1). Any cancer curatively treated \> 3 years prior to enrollment is permitted.
* Any condition that in the opinion of the investigator would impair participation in the trial.
* Coinfected with human immunodeficiency virus (HIV) infection or Hepatitis B virus (e.g. HBsAg positive).
* History of congestive heart failure defined as Class II to IV per New York Heart Association (NYHA) classification within 6 months prior to study entry; active coronary artery disease (CAD); clinically significant bradycardia or other uncontrolled, cardiac arrhythmia defined as ≥ Grade 3 according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), version 4.03, or uncontrolled hypertension; myocardial infarction occurring within 6 months prior to study entry (myocardial infarction occurring \> 6 months prior to study entry is permitted)
* Active clinically serious infections defined as ≥ Grade 3 according to NCI CTCAE, version 4.03 6. Any medical, psychological, or social conditions, particularly if unstable, including substance abuse, that may, in the opinion of the Investigator, interfere with the subject's safety or participation in the study, protocol compliance, or evaluation of the study results
* Concomitant interferon therapy or therapies for active Hepatitis C Virus (HCV) infection. Prior interferon and/or ribavirin therapy is not a contraindication to enrolment however previous treatment with direct acting antiviral treatment is an exclusion
* Pregnancy or breast-feeding
* Inability to swallow oral medications
* Clinically significant gastrointestinal bleeding occurring ≤ 3 months prior to study entry or Large gastric-esophageal varices (larger than 5 cm) or previous history of gastric-esophageal bleeding due to varices.
* Fulfills exclusion criteria on biochemistry results:

  * Creatinine Clearance \<50 mL/min
  * Hemoglobin \<11 g/dL for females and \<12 g/dL for males
  * Platelets \<75 x 103/μL
  * Serum Albumin \< 3.0 g/dL
  * INR \>1.7
  * HbA1c \>10%
  * ALT \>10XULN, AST \>10XULNtherapy