Clinical trial · Interventional
One Versus Two Unit Transfusions in Oncology Patients - The OTTOP Trial: A Randomized Open-label Pragmatic Controlled Trial
NCT04544540CI-TRIAL-00047073OTTOPunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this trial is to determine if the transfusion of one unit of red blood cells to anemic oncology patients results in comparable numbers of transfusion episodes when compared to transfusion of two units of red blood cells.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anemia | — | UNRESOLVED | — |
| Oncology | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Units of transfusion | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- One-Unit
- description
- Patients will be randomized to receive 1-unit of red blood cell transfusions as an outpatient a period of one-year. At each outpatient transfusion episode, the patient will receive a transfusion of 1-unit
- interventionNames
- Other: Units of transfusion
- type
- EXPERIMENTAL
- label
- Two-Unit
- description
- Patients will be randomized to receive 2-unit sof red blood cell transfusions as an outpatient a period of one-year. At each outpatient transfusion episode, the patient will receive a transfusion of 2-units
- interventionNames
- Other: Units of transfusion
Primary outcomes (1)
- measure
- number of transfusion episodes in the 1-year after randomization
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults over 18 years of age with solid tumour (non-hematologic) malignancy undergoing chemotherapy * Requiring a red blood cell transfusion as determined by their treating oncologist Exclusion Criteria: * Active bleeding (WHO grade 3 and 4) * Known history active hemolysis * Inpatient admission * Refusal to receive red blood cell transfusion * Unwilling or unable to provide informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.