Clinical trial · Interventional
Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
Metabolic Imaging of Patients With Lower Grade Glioma Using Hyperpolarized 13C Pyruvate
NCT04540107CI-TRIAL-00109745recruitingPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies how well serial magnetic resonance (MR) imaging and MR spectroscopic imaging work in characterizing lower grade glioma. Diagnostic procedures, such as MR imaging and MR spectroscopic imaging, may detect serial changes in lower grade glioma. This study may help researchers learn more about practical ways of evaluating and standardizing treatment in patients with brain tumors.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent WHO Grade III Glioma | WHO Grade 3 Glioma | CURATED_BROADER | 0.78 |
| Recurrent World Health Organization (WHO) Grade II Glioma | Glioma | PROBABILISTIC | 0.70 |
| WHO Grade II Glioma | WHO Grade 2 Glioma | ALIAS | 0.90 |
| WHO Grade III Glioma | WHO Grade 3 Glioma | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hyperpolarized Carbon C 13 Pyruvate | Drug | — | UNRESOLVED |
| Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Magnetic Resonance Spectroscopic Imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cohort 1 (MRI, MRSI) (CLOSED TO ENROLLMENT)
- description
- Patients undergo MRI and MRSI scans over 1 hour at baseline. Patients then continue to undergo MRSI scans that follow the clinical MRI schedule set by doctors to monitor patients' care. Participants enrolled in cohort 1 may later enroll in cohort 2 of study once eligibility has been reviewed and approved by neuro-oncologist
- interventionNames
- Procedure: Magnetic Resonance Imaging
- Procedure: Magnetic Resonance Spectroscopic Imaging
- type
- EXPERIMENTAL
- label
- Cohort 2 (MRI, hyperpolarized carbon C 13 pyruvate, MRSI)
- description
- Patients undergo MRI scan at baseline. Patients then receive hyperpolarized carbon C 13 pyruvate IV over less than 1 minute and undergo MRSI scan at baseline. Patients then continue to undergo MRSI scans that follow the clinical MRI schedule set by doctors to monitor patients' care.
- interventionNames
- Drug: Hyperpolarized Carbon C 13 Pyruvate
- Procedure: Magnetic Resonance Imaging
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * For patients in cohort 1: histologically proven lower grade glioma who are being followed with surveillance scans * For patients in cohort 2: histologically proven glioma who are scheduled for treatment due to suspected residual or recurrent tumor * Patients with a life expectancy \> 12 weeks * Patients must have a Karnofsky performance status of \>= 60 * Patients must have adequate renal function (creatinine \< 1.5 mg/dL) before imaging. These tests must be performed within 60 days prior to the hyperpolarized imaging scan. * Patients must not have any significant medical illnesses that in the investigator's opinion cannot be adequately controlled with appropriate therapy, would compromise the patient's ability to participate in this study or any disease that will obscure toxicity or dangerously impact response to the imaging agent. * Patients must not have New York Heart Association (NYHA) grade II or greater congestive heart failure * Patients must not have history of myocardial infarction or unstable angina within 12 months prior to study enrollment * This study was designed to include women and minorities, but was not designed to measure differences of intervention effects. Males and females will be recruited with no preference to gender. Minorities will actively be recruited to participate. No exclusion to this study will be based on race * Patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must sign an authorization for the release of their protected health information * Patients may not be known to be human immunodeficiency virus (HIV)-positive. HIV testing is not required for study participation * Patients must not have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless they are in complete remission and have been off all therapy for that disease for a minimum of 3 years * Patients must not be pregnant or breast-feeding. Women of childbearing potential are required to obtain a negative pregnancy test within 14 days of hyperpolarized imaging scan. Effective contraception (men and women) must be used in subjects of child-bearing potential Exclusion Criteria: * Subjects will be excluded from participating in this study if they are unable to comply with study and/or follow-up procedures
References
Publications (0)
Data not yet available
No reference posted for this study.