Clinical trial · Observational
Evaluation of Changes in Brain Connectivity After Tumor Resection
NCT04536142CI-TRIAL-00070069completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is being done to see the changes in structural and functional connectivity that happen in the brain of patients undergoing brain tumor surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI | Diagnostic Test | — | UNRESOLVED |
| neuropsychological tests and qualitative assessment | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Brain tumors
- description
- Subjects with operable supratentorial brain tumors
- interventionNames
- Diagnostic Test: MRI
- Diagnostic Test: neuropsychological tests and qualitative assessment
- label
- Healthy subjects
- description
- Healthy subjects
- interventionNames
- Diagnostic Test: MRI
- Diagnostic Test: neuropsychological tests and qualitative assessment
Primary outcomes (2)
- measure
- Brain connectivity changes
- timeFrame
- MRI scan will be performed within 1 week prior to surgery and again 2 weeks after surgery.
- description
- With both the functional and structural connectomes created, the investigators will compute graph network measures before and after surgical resection and assess both nodal and global network measures.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. Brain tumor subjects (27) * informed consent * age equal to or greater than 19 years (age of majority in Nebraska) * brain tumor that requires surgery * primary or metastatic brain tumor 2. Healthy subjects (3) * informed consent * age equal to or greater than 19 years (age of majority in Nebraska) * healthy subject with no know neurocognitive deficiencies Exclusion Criteria: * any contraindication to MRI (i.e. implanted devices) * inappropriate body habitus for MRI * no capacity to understand the study the study or consent to it * positive pregnancy test in females * end stage renal disease or severe renal dysfunction * severe anxiety disorder * metabolic encephalopathy * significant medical co-morbidities precluding a safe surgery * need for sedation for MRI
References
Publications (0)
Data not yet available
No reference posted for this study.