Liver Disease and Other Systemic Diseases

Arms (0)

Primary outcomes (2)

1. measure

   The incidence of a new diagnosis of hepatocellular carcinoma (HCC)

   timeFrame

   From the date of enrollment until the date of first documented diagnosis of HCC, assessed up to 120 months.

   description

   The new diagnosis of HCC is assessed every 3 months by abdominal sonography, and every 6 months with tumor markers (e.g. AFP), and confirmed by dynamic CT or MRI or pathological examination.

2. measure

   The incidence of a new diagnosis of any event of liver cirrhosis complications

   timeFrame

   From the date of enrollment until the date of first documented any event of liver cirrhosis complications, or date of death from any cause, whichever came first, assessed up to 120 months.

   description

   Liver cirrhosis complications include ascites, esophageal or gastric varices bleeding, hepatorenal syndrome, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatic pulmonary syndrome, liver failure (Child-Pugh score B or C), or liver transplant, that are assessed every 3 months clinically. A new diagnosis of any event of liver cirrhosis complications is a new documented any of the above liver cirrhosis complications, whichever came first.