Clinical trial · Observational
Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In order to more accurately discover the cause of drug resistance in tumor treatment, and to provide a new basis for precise treatment. Therefore, based on the umbrella theory of precision medicine, we carried out this single-center, prospective, and observational study to include patients with liver metastases from colorectal cancer. By combining genome, transcriptome, and proteomic sequencing data, we established a basis for colorectal cancer liver Transfer the multi-omics data of the sample, describe the reason for the resistance of the first-line treatment, and search for new therapeutic targets.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer Metastatic | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Multi-omics | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Multiomics arm
- description
- Guide therapy based on multi-omics
- interventionNames
- Diagnostic Test: Multi-omics
Primary outcomes (1)
- measure
- Objective response rate
- timeFrame
- 1 year
- description
- Refers to the proportion of patients whose tumors have shrunk to a certain amount and maintained for a certain period of time, including complete remission (CR) and partial remission (PR) cases
Secondary outcomes (2)
- measure
- progression-free survival
- timeFrame
- 1 year
- description
- Refers to the date from initial diagnosis to tumor progression
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * ECOG score 0-2 points * Pathologically diagnosed patients with colorectal cancer * Combined with liver metastases confirmed by imaging, and the lesion is measurable (RECIST standard) * The lesion is available * First-line treatment failed; hematology, liver and kidney function tests are suitable for back-line treatment * Informed consent Exclusion Criteria: * With brain metastases * History of other malignancies * Pregnancy or breastfeeding * Have received other drug clinical studies within 30 days before the start of this study
References
Publications (0)
Data not yet available