Clinical trial · Observational
Preemptive and Precise Intervention for CKD-SHPT
Preemptive Surgical Intervention and Precise Efficacy Evaluation for Hyperparathyroidism Secondary to Chronic Kidney Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Through multi-center randomized controlled trial studies on preemptive surgical intervention in patients with chronic kidney disease (CKD) - secondary hyperparathyroidism (SHPT), to precisely evaluate the safety and effectiveness during perioperative period, and the long-term outcomes by 1-year follow-up. The follow-ups include the evaluation of the overall quality of life, calcium and phosphorus metabolism, hyperparathyroidism level, vitamin D metabolism, bone mineral density, soft tissue and vascular calcification.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hyperparathyroidism; Secondary, Renal | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Preemptive Surgical Intervention and Precise Efficacy Evaluation of CKD-SHPT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Preemptive and Precise Intervention
- description
- Preemptive surgical intervention will be performed on enrolled CKD-SHPT patients. Safety and efficacy of this intervention will be evaluated during peri-operative period, and long-term outcomes will be analyzed during 1-year follow-up.
- interventionNames
- Procedure: Preemptive Surgical Intervention and Precise Efficacy Evaluation of CKD-SHPT
Primary outcomes (2)
- measure
- Safety of preemptive surgical intervention
- timeFrame
- October 2020 to September 2022
- description
- The rate of post operative complications(including bleeding, infection, adjacent tissue injury) of early precise parathyroidectomy surgery in patients with CKD-SHPT, according to the electronic medical records of the hospital.
- measure
- Efficacy of preemptive surgical intervention
- timeFrame
- October 2020 to September 2022
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 1\) Chronic Kidney Disease Stage 3-5d patients aged ≥18 years; * 2\) The diagnosis is consistent with CKD-metabolic bone disease and SHPT after evaluation by a kidney specialist; * 3\) Sustained blood immunoreactive parathyroid hormone level of \> 300ng/ml, and had received drug treatment; * 4\) Persistent hypercalcemia and/or hyperphosphatemia that is not responding to medication; * 5\) Imaging suggested evidence of at least one parathyroid nodular hyperplasia; * 6\) Signed the informed consent. Exclusion Criteria: * 1\) Age \<18 years old; * 2\) Patients with dialysis duration \< 3 months, or with other unstable dialysis state; * 3\) Kidney transplant patients; * 4\) Who is considered inappropriate to participate in this study after evaluation by the supervising physician.
References
Publications (0)
Data not yet available