Clinical trial · Interventional
Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
NCT04516174CI-TRIAL-00046675unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aged | — | UNRESOLVED | — |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Saline | Drug | — | UNRESOLVED |
| Transversus abdominis plane block using ropivacaine | Procedure | — | UNRESOLVED |
| Transversus abdominis plane block using saline | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dex+TAPB group
- description
- Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.
- interventionNames
- Procedure: Transversus abdominis plane block using ropivacaine
- Drug: Dexmedetomidine
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.
- interventionNames
- Procedure: Transversus abdominis plane block using saline
- Drug: Saline
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 65-80 years,regardless of gender * American Society of Anesthesiologists physical status I-III * Undergoing elective radical resection of colorectal cancer * Sign informed consent Exclusion Criteria: * Could not cooperate to complete the pain VAS evaluation * Could not cooperate to complete the cognitive function assessment
References
Publications (0)
Data not yet available
No reference posted for this study.