Clinical trial · Interventional
Circulating " Cancer Cells / Macrophage " HYbrid Cells in Patients With Sarcoma?
NCT04512495CI-TRIAL-00055470SAMHY SARCOMEcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pilot, prospective, monocentric study aimed at evaluating the rate of patients with circulating "cancer cell/macrophage" hybrid cells in the peripheral blood. The study will be conducted on a population of patients with sarcoma and treated in the context of routine care. For each included patient, blood samples will be collected during baseline visit and after the initiation therapy. At the end of the 2nd blood collection, the patient will have completed his participation in the study.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood samples will be collected at two times : | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients with sarcoma
- interventionNames
- Other: Blood samples will be collected at two times :
Primary outcomes (1)
- measure
- Rate of patients with "cancer cell / macrophage" hybrid cells in peripheral blood.
- timeFrame
- 6 months after the end of inclusions
Secondary outcomes (1)
- measure
- Quantification of circulating hybrid cells in peripheral blood by automatic measurement (Cell Counter Corning) and expressed in number of cells / millilitre of blood.
- timeFrame
- 6 months after the end of inclusions
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patient with one of the following subtypes of soft tissue or bone sarcomas: leiomyosarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, synovialosarcoma, osteosarcoma, Ewing's sarcoma. 2. Diagnosis of sarcoma histologically confirmed by the RRePS network (Réseau de Référence en Pathologie des Sarcomes et des Viscères) 3. Age ≥ 18 years old. 4. Localized or metastatic disease or recurrent disease. 5. Patient who has not yet initiated specific treatment for sarcoma. 6. Patient affiliated to a Social Health Insurance in France. 7. Patient having signed informed consent prior to inclusion in the study and prior to any specific study procedures. Exclusion Criteria: 1. Patient with any other histological subtype of sarcoma, including pleomorphic sarcoma. 2. Associated pathology(s) that may prevent the proper conduct of the procedure under consideration. 3. Pregnant or breastfeeding woman. 4. Any psychological, family, geographical or sociological condition that prevents compliance with the medical follow-up and/or procedures of the study protocol. 5. Patient who has forfeited his/her freedom by administrative or legal award or who is under legal protection (curatorship and guardianship, protection of justice).
References
Publications (0)
Data not yet available
No reference posted for this study.