Clinical trial · Interventional
Effects of Anesthetic Methods on Hepatic Cancer Cell Function in Vitro
Effects of Serum From Hepatocellular Carcinoma Surgery Patients Under Different Anesthetic Methods on Hepatic Cancer Cell Function in Vitro
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Numerous studies find that anesthetic methods may influence the recurrence of tumor and the overall survival of patients after primary cancer surgery. Radiofrequency (RF) ablation is now widely used in the clinic for treatment of hepatocellular carcinoma (HCC). Currently, diverse anesthetic methods, including general anesthesia (GA), epidural anesthesia and local anesthesia (LA), are used for RF ablation surgery. Using serum from HCC surgery patients randomized to receive either GA or LA during surgery, we will investigate the effects of anesthetic methods on cellular invasion, migration and proliferation of HepG2 hepatic cancer cells in vitro. The expression levels of inflammatory cytokines in the serum from patients of both groups will also be analyzed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| general anesthesia | Procedure | — | UNRESOLVED |
| local anesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- general anesthesia
- description
- Patients in this group will have RF ablation for treatment of HCC under general anesthesia.
- interventionNames
- Procedure: general anesthesia
- type
- ACTIVE_COMPARATOR
- label
- local anesthesia
- description
- In this group, patients will receive radiofrequency ablation under local anesthesia.
- interventionNames
- Procedure: local anesthesia
Primary outcomes (1)
- measure
- mean percentage change from post- to pre-operative values of invasion of HepG2 cells cultured in patients' serum
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * 18 to 65 years old * ASA grade I-III * Diagnosed with a single primary liver tumor of 3cm or smaller * Is scheduled for elective radiofrequency ablation surgery * With no macro-vascular invasion, no lymph node or extrahepatic metastases * Child-Pugh Class A or B Exclusion Criteria: * a history of liver surgery previously (including radiofrequency ablation) * severe systemic disease (heart, lung, kidney, or immune system) * INR\>1.5 or platelet count \<45,000 cells/mm3 * a history of addiction to opioids; * Disagree to participate the trial
References
Publications (1)
- DERIVEDNunez-Rodriguez E, Zhang H, Sah D, Cata JP. Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? Adv Biol (Weinh). 2025 Oct;9(10):e00122. doi: 10.1002/adbi.202500122. Epub 2025 Aug 7. PMID 40772525