Clinical trial · Observational
Measurement of Diaphragmatic Dysfunction After Thoracic Surgery
Measurement of Diaphragmatic Dysfunction in Patients Undergoing Thoracic Resection Surgery for Lung- or Esophageal Cancer
NCT04507594CI-TRIAL-00061839completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of diaphramatic function to clinical postoperative endpoints.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Diaphragm Injury | — | UNRESOLVED | — |
| Phrenic Nerve Paralysis | — | UNRESOLVED | — |
| Postoperative Complications | — | UNRESOLVED | — |
| Thoracic Cancer | Malignant Thoracic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lung lobectomy OR esophagus cancer resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients undergoing Thoracic Surgery
- interventionNames
- Procedure: Lung lobectomy OR esophagus cancer resection
Primary outcomes (1)
- measure
- Change in excursion of the diaphragm
- timeFrame
- Prior to surgery to 14 days after surgery
- description
- Ultrasonographic measure with M-mode of Diaphragmatic Excursion on right hemidiaphragm
Secondary outcomes (15)
- measure
- Ultrasonographic measure of the difference in Intrathoracic Area
- timeFrame
- Prior to surgery to 14 days after surgery
- description
- Intrathoracic Area is measured at inspiration and expiration to calculate the difference in Intrathoracic Area during breathing
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Scheduled thoracic resection Surgery for lung- or esophagus cancer. For lung cancer patients, at least one lung lobe has to scheduled for resection Exclusion Criteria: * Known Diaphragmatic Dysfunction * Neuromuscular Disease * Pleural Effusion \> 1cm * Pneumothorax * Known Phrenic Nerve Palsy
References
Publications (1)
- DERIVEDNorskov J, Skaarup SH, Bendixen M, Tankisi H, Morkved AL, Juhl-Olsen P. Diaphragmatic dysfunction is associated with postoperative pulmonary complications and phrenic nerve paresis in patients undergoing thoracic surgery. J Anesth. 2024 Jun;38(3):386-397. doi: 10.1007/s00540-024-03325-5. Epub 2024 Mar 28. PMID 38546897