Treating Locally Advanced Head and Neck Malignant Tumor With Anlotinib and Chemoradiotherapy

Inclusion Criteria:

* Male or female, aged 18 to 75 years;
* Performance status (PS) score ≤ 1 points;
* The expected survival period is more than 3 months;
* Highly differentiated squamous cell carcinoma or non-squamous cell carcinoma of the head and neck diagnosed by pathology and/or cytology, including sarcoma, adenoid cystic carcinoma, olfactory blastoma, mucoepidermoid carcinoma, etc.; those whose primary tumor cannot be cured by surgery;
* With measurable lesions: According to the evaluation criteria for the efficacy of solid tumors (Response Evaluation Criteria In Solid Tumors 1.1), the patient has at least one measurable lesion. The measurable lesion should not have received local treatment such as radiotherapy (target lesion located in the previous radiotherapy area, if it is confirmed that significant progress has occurred , And comply with evaluation standard, can also be used as target lesions);
* No previous anti-tumor therapy, including anti-angiogenesis therapy, such as pazopanib, sunitinib, sorafenib, regorafenib, etc.;
* Sufficient liver function: total bilirubin ≤ upper limit of normal value (ULN); glutamic oxalacetic transaminase (AST) and glutamic-pyruvic transaminase (ALT) ≤ 2 times upper limit of normal value (ULN); alkaline phosphatase ≤ 5 times upper limit of normal value (ULN);
* Adequate renal function: creatinine clearance rate ≥80 mL/min;
* Adequate blood function: absolute neutrophil count (ANC) ≥2×109/L, platelet count ≥100×109/L and hemoglobin ≥9g/dL;
* No serious heart, lung and other important organ dysfunction;
* Women of childbearing age must have taken reliable contraceptive measures; pregnancy tests (serum or urine) are negative within 7 days before enrollment, and must be non-lactating patients; and are willing to adopt appropriate during the test and within 6 months after the last treatment Methods of contraception. For men, it is necessary to agree to use appropriate methods of contraception or surgical sterilization during the trial and 8 weeks after the last dose;
* The subjects voluntarily joined the study and signed an informed consent form with good compliance and cooperated with the follow-up.

Exclusion Criteria:

* Can undergo radical surgery or cannot tolerate anti-tumor treatment;
* Women who are pregnant or breastfeeding, have fertility but are unwilling or unable to take effective contraceptive measures;
* People with high blood pressure who cannot be well controlled by antihypertensive drugs (systolic blood pressure\> 150 mmHg, diastolic blood pressure\> 100 mmHg);
* Patients with clinically significant cardiovascular disease within 6 months before enrollment, including uncontrolled hypertension, myocardial infarction, or unstable angina; New York Heart Association (NYHA) congestive heart failure of grade II or higher, severe Of arrhythmia requiring treatment (including QT interval ≥440 ms), or cardiac ejection fraction \<50%, peripheral vascular disease of grade II or higher;
* Abnormal blood coagulation function (INR\>1.5 or prothrombin time (PT)\>ULN+4 seconds or activated partial thromboplastin time (APTT) \>1.5 ULN), have bleeding tendency or are undergoing thrombolysis or anticoagulation treatment;
* There was obvious hemoptysis blood 2 months before enrollment, or the daily hemoptysis amount was 2.5ml or more;
* Significant clinically significant bleeding symptoms or clear bleeding tendency, such as gastrointestinal bleeding, hemorrhagic gastric ulcer, baseline occult blood ++ and above, or suffering from vasculitis within 3 months before enrollment; Known hereditary or acquired bleeding and thrombotic tendency;
* Arterial/venous thromboembolic events within 12 months before enrollment;
* Have undergone major surgery within 4 weeks of enrollment or accompanied by severe, non-healing wounds, ulcers or fractures;
* There are obvious factors that affect the absorption of oral drugs;
* Abdominal fistula, gastrointestinal perforation or abdominal abscess occurred 6 months before enrollment;
* Urinary routines suggest that urine protein is ≥++, and that the amount of urine protein in 24 hours is ≥1.0g;
* Serous cavity fluid accumulation with clinical symptoms and requiring symptomatic treatment;
* Active infections require antimicrobial treatment;
* Have a history of central nervous system diseases, including primary brain tumors, seizures without standard medication, any brain metastases or have cerebrovascular accidents (CVA, stroke), transient ischemic attack (TIA), or 6 A history of subarachnoid hemorrhage within the month;
* Participated in clinical trials of other drugs 4 weeks before enrollment;
* Other malignant tumors in the past or at the same time (except for malignant tumors that have been cured and survived for more than 5 years without cancer, such as basal cell carcinoma of the skin, carcinoma in situ of the cervix, and papillary thyroid carcinoma, etc.);
* Those who have received VEGFR inhibitors, such as pazopanib, sunitinib, sorafenib, regorafenib, etc.;
* Those who are known to have a history of psychotropic substance abuse, alcoholism or drug use and are unable to quit or have mental disorders;
* The investigator judges other conditions that may affect the progress of the clinical study and the judgment of the research results.