Clinical trial · Interventional
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
Prospective Observational Trial of Two Neoadjuvant Hypofractionated Radiotherapy Regimens Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Soft Tissue Sarcomas | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Moderately-Hypo-fractionation Radiotherapy | Radiation | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
| Resection | Procedure | — | UNRESOLVED |
| Ultra-Hypo-fractionation Radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group I (UH HRT)
- description
- Patients undergo HRT daily for a total of 5 fractions followed by surgery.
- interventionNames
- Radiation: Ultra-Hypo-fractionation Radiotherapy
- Procedure: Resection
- Other: Questionnaire Administration
- type
- EXPERIMENTAL
- label
- Group II (MH HRT)
- description
- Patients undergo HRT daily for a total of 15 fractions followed by surgery.
- interventionNames
- Procedure: Resection
- Other: Questionnaire Administration
- Radiation: Moderately-Hypo-fractionation Radiotherapy
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location) * ECOG performance status 0-2 * Patient must be deemed able to comply with radiation treatment and surgery Exclusion Criteria: * History of prior radiation to the same area to be irradiated * Pregnancy * Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects
References
Publications (0)
Data not yet available