Clinical trial · Observational
S100B in Intensive Care Patients With and Without Traumatic Brain Injury
S100B in Intensive Care Patients With and Without Traumatic Brain Injury: Implications for Neuromarker Assessment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The neurotrophic protein S100B has been promoted as a neuromarker for decades, and to reflect the severity of brain injury. On the other hand, S100B is a tumor marker. The interpretation of its serum levels may be altered by a contribution from extracerebral sources and its renal elimination. In the present study we investigate the relevance of S100B as a prognostic factor, as well as the correlation with different CT classifications in a large cohort of patients with and without brain injury. Furthermore, we examine whether S100B is elevated in brain tumors.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Injuries | — | UNRESOLVED | — |
| Critical Illness | — | UNRESOLVED | — |
| Surgery--Complications | — | UNRESOLVED | — |
| Trauma Injury | — | UNRESOLVED | — |
| Tumor | Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood, cerebrospinal fluid and urine samples | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- ICU TBI
- description
- Patients treated on the ICU with brain injury
- interventionNames
- Diagnostic Test: Blood, cerebrospinal fluid and urine samples
- label
- ICU tumor
- description
- Patients treated on the ICU because of intracranial tumor
- interventionNames
- Diagnostic Test: Blood, cerebrospinal fluid and urine samples
- label
- ICU surgery
- description
- Patients treated on the ICU following surgery without brain injury
- interventionNames
- Diagnostic Test: Blood, cerebrospinal fluid and urine samples
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients of the Department of Neurosurgery, University of Erlangen Nürnberg, patients with traumatic brain injury, * patients with intracranial tumor, * intensive care patients, * informed written consent was given by the Patient or the next of kin in each case. Exclusion Criteria: * age under 18 * pregnancy
References
Publications (0)
Data not yet available