Clinical trial · Interventional
Simultaneous Integrated Boost vs. Routine IMRT in Limited-stage Small-cell Lung Cancer
A Randomized Phase III Study of Comparison Between Simultaneous Integrated Boost (SIB) Intensity-modulated Radiation Therapy (IMRT) Versus Routine IMRT/VMAT in LD-SCLC
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Thoracic radiotherapy concurrent with chemotherapy stands for the standard regime for limited staged small cell lung cancer. Involved node radiation（INF） replaced elective node irradiation（ENI） as the more popular since several trails compared the two regimes. simultaneous integrated boost IMRT becomes mature with advancing in IMRT and VMAT. The investigator hypothesis that SIB-IMRT can confine the dose for organs at risk to reduce the toxicities compared with routine IMRT in limited disease small-cell lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Small-cell Lung Cancer | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| routine IMRT | Radiation | — | UNRESOLVED |
| SIB-IMRT | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- SIB-IMRT
- description
- patients received radiotherapy using IMRT or VMAT，60Gy is given to the field of tumor and metastatic lymph nodes and 50Gy given to CR lesion and high-risk area.concurrent or sequential with 4-6 circles of chemotherapy of EP.
- interventionNames
- Radiation: SIB-IMRT
- type
- OTHER
- label
- routine
- description
- patients received IMRT or VMAT，with the prescription of 60Gy/2Gy/30F to the planning tumor volume ，concurrent or sequential with EP chemotherapy
- interventionNames
- Radiation: routine IMRT
Primary outcomes (1)
- measure
- progress-free survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * 18-70 years old,KPS≥80 * pathological small cell lung cancer * staged as limited disease SCLC（contralateral hilar invasion not included） * receive radiotherapy concurrent or sequential with chemotherapy，if induction chemotherapy，got PR or SD * no other tumors * No serious medical diseases and dysfunction of major organs * understand this study，able to complete the treatment，accept the following up and sign the informed consent * Contraception in women of childbearing age. Exclusion Criteria: * other malignant tumor（historically or simultaneously）curable non-melanoma skin cancer and cervical carcinoma in situ not included * Uncontrolled heart disease or myocardial infarction within 6 months * History of mental illness * Pregnancy or Lactation * uncontrolled diabetes、hypertension
References
Publications (0)
Data not yet available