Clinical trial · Observational
Perioperative Care in the Cancer Patient -1, ARCA-1 Study
ARCA-1 Study: Perioperative Care in the Cancer Patient -1
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study investigates the association of blood transfusions given around the time of surgery (perioperative) with complications after surgery (postoperative), cancer progression, and mortality after major oncologic non-cardiac surgery. The administration of blood products is an important clinical therapy to treat life-threatening blood (hematological) disorders (i.e. anemia, coagulation disorders or thrombocytopenia) in patients with cancer undergoing major non-cardiac surgery. On the other hand, the unnecessary exposure of those patients to blood products can be associated with the occurrence of unwanted severe complications and potentially increase the risk of death. An accurate understanding of the short and long-term outcomes, the patterns of blood transfusions, and the triggers of blood product administration may help researchers design and test the safety of perioperative blood transfusions in patients with cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hematopoietic and Lymphoid Cell Neoplasm | Hematopoietic and Lymphoid Cell Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Malignant Solid Neoplasm | Malignant Solid Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Best Practice | Other | — | UNRESOLVED |
| Medical Chart Review | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Observational (standard of care, medical chart review)
- description
- Patients undergo standard of care treatment and their medical records are reviewed at 30 days and at 1 year after surgery.
- interventionNames
- Other: Best Practice
- Other: Medical Chart Review
Primary outcomes (1)
- measure
- All causes of mortality
- timeFrame
- 1 year after major oncologic non-cardiac surgery
Secondary outcomes (4)
- measure
- Cancer-specific mortality
- timeFrame
- 1 year after major oncologic non-cardiac surgery
- measure
- Progression free survival (PFS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient undergoing major cancer surgery with curative intent * Planned length of stay 24 hours after surgery or longer * American Society of Anesthesiologists physical status (ASA) 1-4 * Scheduled, non-emergency surgery Exclusion Criteria: * Emergency surgery * Palliative surgeries for metastatic disease (non-curative intent) * Patients undergoing surgery with minimum risk (\< 1%) of blood transfusion according to each center practice (i.e. simple mastectomy, thyroidectomies or wide-local excisions) * Patients undergoing surgery under local anesthesia * Patients undergoing ambulatory surgery or planned hospital admission of less than 24 hours
References
Publications (2)
- DERIVEDCata JP, Guerra-Londono JJ, Ramirez MF, Chen LL, Warner MA, Guzman LFC, Lobo F, Uribe-Marquez S, Huang J, Ruscic KJ, Chew STH, Lanigan M; ARCA-1 Investigators. The Association Between Perioperative Red Blood Cell Transfusions and 1-Year Mortality After Major Cancer Surgery: An International Multicenter Observational Study. Anesth Analg. 2025 Apr 1;140(4):782-794. doi: 10.1213/ANE.0000000000007236. Epub 2024 Nov 6. PMID 39504267
- DERIVEDCata J, Ramirez M, Forget P, Chen LL, Diaz-Cambronero O, Chen W, Warner MA, Knopfelmacher Couchonal A, Pelosi P, Cuellar L, Corrales G, Romero C, Lobo F, Saager L, Castro Tapia J, Kiberenge R, Feng L, Serpa Neto A. International multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocol. BMJ Open. 2021 Mar 18;11(3):e043453. doi: 10.1136/bmjopen-2020-043453. PMID 33737431