Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patients

Inclusion Criteria:

* Must be informed of the investigational nature of this study and must provide written informed consent
* Age ≥18 years, male or female
* Must have clinically and histologically confirmed recurrent intermediate and high-risk non-muscle invasive transitional cell carcinoma of the bladder after treatment with intravesical chemotherapy. EORTC risk score (according to EUA "NMIBC Guideline" 2015 version) must be ≥ 5: Papilloma alone (or with Cis) or Cis alone No visible tumor after TURBT on tumor lesion
* Medical history of intravesical chemotherapy Subjects who received intravesical chemotherapy prior to enrollment, but didn't receive BCG or other intravesical therapy with immune drugs Subjected who are refractory to the recommended intravesical chemotherapy drugs pirarubicin, epirubicin, doxorubicin, hydroxy camptothecin, mitomycin, or gemcitabine (according to "Guideline of Diagnosis and Treatment of Urological Diseases in China", 2014 version)
* Re-TURBT:

For subjects undergoing secondary TURBT, EORTC risk score must be ≥ 5, which can be assessed based on the results of any TURBTs. The other results will be based on first TURBT For subjects undergoing secondary TURBT, the enrollment time will start from the second TURBT It is recommended to conduct the secondary TURBT under following situations: incomplete first TURBT; no muscle tissue found in the first TURBT specimen, except Ta G1 (low grade) tumor and CIS only; T1 tumor; G3 (high grade) tumor (except CIS) The secondary TURBT is recommended 2-6 weeks, but better at 4 weeks, after the first TURBT

* Willing to provide biopsy specimen for assessment
* ECOG PS ≤ 1, and did not deteriorate in 7 days
* Patients must have normal organ and marrow function within 42 days of study entry (according to normal range in clinical site) Absolute neutrophil count \>1.0×109/L Platelets \> 100 ×109/L Hemoglobin \> 9.0 g/dl Alkaline phosphatase \< 2.5 ULN (\<10 X ULN in presence of bone metastasis) GFR (Cockcroft-Gault formula calculated) ≥ 50 ml/min INR \<1.5, except for subjects receiving warfarin therapy
* Eligibility of patients receiving any medications or substances known to affect or with the potential to affect the activity or pharmacokinetics of APL-1202 will be determined following review of their case by the Principal Investigator
* Female should be either surgically sterilized or menopause or agree to use effective contraceptive measures during treatment
* Male subjects must be surgically sterilized or agreed to use effective contraceptive measures. Subjects must continue to take contraceptive measures within 3 months of the end of the study treatment. The definition of effective contraceptive measures will be based on the Principal Investigator or appointed delegate;
* Expected life expectancy is more than 30 months

Exclusion Criteria:

* TBIL, ALT or AST \>1.5 x normal range (according to normal range in clinical sites)
* Urothelial cell carcinoma in upper urethra or ureter
* Received intravesical therapy in last TURBT/cystoscopy prior to enrollment period, but not including immediate intravesical therapy once (the subjects who received the immediate intravesical therapy need to be recorded in e-CRF)
* Received surgery (not includes TURBT/cystoscopy), radiation therapy, or systemic therapy within 6 weeks before enrollment
* Malignancies within 2 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "in-situ' of the cervix
* NCI CTCAE grade 3 hemorrhage within 6 weeks of starting study treatment
* Any of the following within 6 months prior to study drug administration: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, or pulmonary embolism
* Hypertension that cannot be controlled by medications
* systolic blood pressure≥140 mmHg and/or diastolic blood pressure≥90mmHg
* Uncontrolled active infections such as acute pneumonia, active hepatitis B, etc.
* Dysphagia or known drug absorption disorders
* Anuria
* One week prior to enrollment, having hematuria
* Active duodenal ulcers, ulcerative colitis and other gastrointestinal diseases or other conditions that the investigator may determine to cause gastrointestinal bleeding or perforation
* Subjects that may increase the risk associated with study participation or study drug administration, judged by investigator, or other severe acute or chronic medical condition or optic nerve disorders may interfere with the interpretation and judgment of study results
* Pregnancy or breastfeeding. Female patients with reproductive potential have a positive pregnancy test prior to enrollment
* Psychological or mental abnormality, subjects are estimated to have insufficient adherence to this clinical study
* Four weeks prior to enrollment, participate in other clinical trials
* Patients who had previously received anthracycline for systemic chemotherapy