Clinical trial · Observational
Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chordomas are very rare malignant tumors, chemo-resistant with high propensity for recurrence. The role of immunotherapy in these patients remains largely unexplored while PD-L1 and CD8 status in the micro-environment of chordomas is basically not known. Similarly, this tumor often poses diagnostic difficulties due to its resemblance with metastasis or chondrosarcoma, thus, it would be useful to know the expression status of factors used during the work-up of metastatic or mesenchymal tumors, like CDX2, INSM1 and FOXA1, which remains unknown for chordomas. Thus, the aim of the study is to explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression in a series of chordomas and compare it with clinico-pathological and prognostic features.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chordoma | Chordoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Analysis Immunohistochemical | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Chordoma
- description
- Patients diagnosed with chordoma
- interventionNames
- Other: Analysis Immunohistochemical
Primary outcomes (5)
- measure
- Expression of PD-L1
- timeFrame
- Baseline
- description
- measured by immunohistochemical method
- measure
- Expression of CD8
- timeFrame
- Baseline
- description
- measured by immunohistochemical method
- measure
- Expression of CDX2
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with chordoma * Sufficient histological material available * Tumor expression of brachyury Exclusion Criteria: \- Insufficient histological material
References
Publications (0)
Data not yet available