Clinical trial · Interventional
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
NCT04479514CI-TRIAL-00114533completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CNS Tumor, Childhood | Childhood Central Nervous System Neoplasm | ALIAS | 0.90 |
| Pediatric Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
| Skin Inflammation | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dilute bleach baths | Other | — | UNRESOLVED |
| Limited Sun Exposure | Behavioral | — | UNRESOLVED |
| Moisturizer | Other | — | UNRESOLVED |
| SPF 30 or Higher Suncreen | Drug | — | UNRESOLVED |
| Sun Protective Clothing | Other | — | UNRESOLVED |
| Warm Baths or Showers | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Preventative Skin Care Routine
- description
- Participants will perform a preventative skin care routine that includes daily sun protection, daily gentle skin care and every-other-day dilute bleach baths for the duration of the study. Participants will receive skin examinations and complete a survey about their skin condition at the initial visit when anti-cancer treatment is started, at six weeks after the start of treatment, and at twelve weeks after the start of treatment.
- interventionNames
- Other: Warm Baths or Showers
- Other: Moisturizer
- Drug: SPF 30 or Higher Suncreen
- Other: Sun Protective Clothing
- Behavioral: Limited Sun Exposure
- Other: Dilute bleach baths
Primary outcomes (1)
- measure
- Rate of Cutaneous Reaction
- timeFrame
- 12 weeks
- description
- Proportion (percentage) of patients with one or more cutaneous reaction to targeted BRAF, MEK, or Pan-RAF inhibitor therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Months
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following: 1. Targeted BRAF inhibitor therapy to treat the brain tumor 2. Targeted MEK inhibitor therapy to treat the brain tumor 3. Targeted pan-RAF inhibitor therapy to treat the brain tumor * Subjects may participate in other studies, including therapeutic trials. * Ability to comply with PSCR including sun protection, gentle skin care and every other day dilute bleach baths. * Ability to understand and/or the willingness of their parent or legally authorized representative to sign a written informed consent document. Exclusion Criteria: * Diagnosed with brain tumor at \> 18 years old * No data in medical records regarding treatment exposures * Treated with a BRAF, MEK or pan-RAF inhibitor in the last three months * Past or present allergic reaction to bleach * Past or present allergic reactions to sunscreen and/or creams, lotions, emollients to be utilized in this study
References
Publications (0)
Data not yet available
No reference posted for this study.