Clinical trial · Observational
Advanced Translational Research on Childhood Leukemia
Driving Therapeutic Progress of Childhood Leukemia Through Advanced Translational Research With Immediate and Long-term Impact. Precision Medicine for Childhood Leukemia.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of \<50%, which is unlikely to be boosted by intensification of standard chemotherapy due to overwhelming toxicity. The advent of effective and safe targeted therapies for high-risk cases is therefore imperative. This study constitutes two research projects aiming at driving therapeutic advances.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Leukemia | Childhood Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cytogenetics test | Other | — | UNRESOLVED |
| RNA-seq | Genetic | — | UNRESOLVED |
| whole exon sequencing | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Childhood Leukemia
- description
- Peripheral blood and bone marrow samples are collected for genetic analysis, invitro drug sensitivity test and animal experiment.
- interventionNames
- Genetic: RNA-seq
- Genetic: whole exon sequencing
- Other: Cytogenetics test
Primary outcomes (4)
- measure
- Genetic alterations of childhood leukemia
- timeFrame
- Baseline
- description
- Association of mutation data with drug sensitivity profiles and disease-free survival /overall survival are analysed using standard statistical methods.
- measure
- Gene expression profiles of childhood leukemia
- timeFrame
- Baseline
- description
- Global transcriptome and fusion transcripts of leukemic blasts are identified by RNA-sequencing.
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
List of inclusion criteria: 1. acute lymphoblastic leukemia (ALL) or 2. acute myeloid leukemia (AML) or 3 .mixed phenotype acute leukemia (MPAL) or 4\. juvenile myelomonocytic leukemia (JMML) or 5\. myelodysplastic syndromes (MDS) or 6\. normal bone marrow donor List of exclusion criteria: 1. This study will not recruit subjects who are unable to understand English or Chinese. 2. Patient or parent refusal
References
Publications (0)
Data not yet available