Healthy Bones, Healthy Life: Habitual Physical Activity on Bone & Metabolic Health in Pediatric Cancer Survivors

This project will examine habitual physical activity, bone health, and insulin resistance in pediatric acute lymphocytic leukemia (ALL) and lymphoma cancer survivors at two time points: baseline and 6 months. At the two study timepoints, all study participants will be asked to wear an accelerometer, receive a DXA scan of the lumbar spine and hip, and have blood drawn for analysis. Study participants will be given a gift card stipend for each study visit attended. Study visits will coincide with regular office visits to Children's Hospital Oncology Clinic and the Children's Hospital Survivorship Clinics whenever possible. The potential mechanism by which physical activity mediates bone changes will be explored by concurrently measuring changes in lean/fat mass and metabolic status. This pilot study will provide data to inform the design of a randomized controlled trial to test the effect of a physical activity intervention on bone health in PCS.

Sex

All

Minimum age

5 Years

Maximum age

18 Years

Inclusion Criteria:

1. Children between the ages of 5-18
2. Diagnosis of ALL or Lymphoma
3. Between 1-13 months post-cancer treatment

Exclusion Criteria:

1. Children younger than 5 years old or 19 or older
2. Children without a diagnosis of ALL or lymphoma
3. Children receiving ongoing cancer treatment
4. Children with Down syndrome (identified as a precancerous condition affecting BMD)
5. Children with a prior history of bisphosphonate use or other medication directed at increasing bone density