Clinical trial · Interventional
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Prehabilitaion Program for Sarcopenic Patients Prior to Pancreaticoduodenectomy for Periampullary Malignant Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The study was terminated prematurely due to patient inclusion difficulties.
Summary
Brief summary (as posted)
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation. However, the rehabilitation concept does not allow to improve muscular and functional reserves at the time of surgery. Sarcopenia is a condition characterized by loss of skeletal muscle mass and function. Also, the prevalence of sarcopenia in patients with cancer is high and has a prevalence of around 25% in patients with pancreatic cancer, with a considerable impact on postoperative and survival outcomes. The hypothesis is the preoperative management of sarcopenia by a rehabilitation program could improve patients' operative outcomes by reducing the rate of postoperative complications.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oral Impact | Dietary Supplement | — | UNRESOLVED |
| Prehabilitation program | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- PREHAB
- interventionNames
- Other: Prehabilitation program
- type
- ACTIVE_COMPARATOR
- label
- control group
- interventionNames
- Dietary Supplement: Oral Impact
Primary outcomes (1)
- measure
- Post-operative severe pancreatic fistula (Grade B and C)
- timeFrame
- at 90 days
- description
- Pancreatic fistula as defined by the International Study Group of pancreatic Fistula (ISGPF)
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing pancreaticoduodenectomy for cancer * Sarcopenic status Exclusion Criteria: * Age younger than 18 years * Medical contraindications including cardiovascular disease or clinically significant vascular disease * Physical inability to exercise * Emergent surgery
References
Publications (0)
Data not yet available