Clinical trial · Observational
Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome
Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome: Study Conducted in the Hauts-de-France
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome. Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen. Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lynch Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| questionnaire assesment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- case group
- description
- Women with Lynch Syndrome and endometrial Cancer matched on age of endometrial cancer diagnosis
- interventionNames
- Other: questionnaire assesment
- label
- control group
- description
- Women with Lynch Syndrome, without Cancer at Lynch Syndrome Diagnostic matched on their age at Lynch Diagnostic
- interventionNames
- Other: questionnaire assesment
Primary outcomes (1)
- measure
- Correlation between endometrial cancer and predictif factors
- timeFrame
- Baseline
- description
- Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Lynch Syndrome Diagnosis at University Hospital * Alive at study time * Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis Case group : \- No cancer before endometrial cancer diagnosis Control group : * No endometrial cancer developped * Free cancer women at Lynch Syndrome diagnosis Exclusion Criteria: * Refusing to participate * Poor understanding of the French language * Other cancer diagnosed before endometrial cancer * Hysterectomy before lynch diagnosis for free cancer women
References
Publications (0)
Data not yet available