Clinical trial · Observational
Advanced Geriatric Evaluation and Quality of Life in Colorectal Cancer Surgery
Advanced Geriatric Evaluation in Predicting Health Related Quality of Life in Patients With Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer (CRC) disproportionately affects patients aged 70 years and older. Surgery is the main treatment modality for CRC, but is associated with increased risk of postoperative morbidity, disability and loss of health related quality of life (HRQL).Frailty is an age related state of functional decline and considered to be an important risk factor for adverse outcome in geriatric oncology.Risk models for adverse outcome may be used for treatment decisions in the elderly, but are often not designed to predict patient related outcome measures and do not include frailty characteristics.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Loss of health related quality of life (HRQL)
- timeFrame
- 12 months
- description
- Change in EORTC QLQ-C30
Secondary outcomes (3)
- measure
- Loss of health related quality of life (HRQL)
- timeFrame
- 3 months
- description
- Change in EORTC QLQ-C30
- measure
- Postoperative complications
- timeFrame
- 30 days
- description
- Complication after surgery
- measure
- Disability
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 70 years * Histologically proven non-metastatic colorectal cancer * Signed informed consent Exclusion Criteria: * \- Emergency surgical procedures * Insufficient understanding of the Dutch language
References
Publications (1)
- DERIVEDvan der Vlies E, Vernooij LM, Hamaker ME, van der Velden AMT, Smits M, Intven MPW, van Dodewaard JM, Takkenberg M, Vink GR, Smits AB, Bos WJW, van Dongen EPA, Los M, Noordzij PG. Frailty and health related quality of life three months after non-metastatic colorectal cancer diagnosis in older patients: A multi-centre prospective observational study. J Geriatr Oncol. 2022 Jan;13(1):74-81. doi: 10.1016/j.jgo.2021.08.005. Epub 2021 Aug 24. PMID 34446378