Clinical trial · Observational
A Study of miRNA 371 in Patients With Germ Cell Tumors
A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors
NCT04435756CI-TRIAL-00105309active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the cancer will come back.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Germ Cell Tumor | Germ Cell Tumor | ONTOLOGY_EXACT | 0.90 |
| Metachronous Malignant Neoplasm | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Seminoma | Seminoma | ONTOLOGY_EXACT | 0.98 |
| Stage IA Testicular Cancer AJCC v8 | Malignant Testicular Neoplasm | CURATED_BROADER | 0.78 |
| Stage IB Testicular Cancer AJCC v8 | Malignant Testicular Neoplasm | CURATED_BROADER | 0.78 |
| Stage IS Testicular Cancer AJCC v8 | Malignant Testicular Neoplasm | CURATED_BROADER | 0.78 |
| Stage I Testicular Cancer AJCC v8 | Malignant Testicular Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biomarker Analysis | Other | — | UNRESOLVED |
| Blood Product Collection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Observational (blood collection)
- description
- Patients undergo collection of blood every 3-6 months for up to 3 years.
- interventionNames
- Other: Biomarker Analysis
- Procedure: Blood Product Collection
Primary outcomes (2)
- measure
- To estimate positive predictive value of miRNA 371 in early stage testicular seminoma and nonseminoma patients
- timeFrame
- Up to 3 years
- description
- Positive predictive value will be estimated using plasma miRNA 371 expression at relapse.
- measure
- To bank blood specimens of patients at low risk and moderate risk of relapse
- timeFrame
- Up to 3 years
- description
- 10 ml whole blood will be collected at time points specified by the protocol.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients must have a new diagnosis of a germ cell tumor. confirmed pathologically or serologically (diagnostic elevation of human chorionic gonadotropin \[HCG\]/alpha-fetoprotein \[AFP\]). All primary sites, stages, histological subtypes of germ cell tumor are eligible. Metachronous second primary germ cell tumors are eligible * If surgery is planned, male patients with clinical stage I testicular cancer must have orchiectomy completed within 42 days prior to registration * Patients must be registered within 42 days after diagnosis and prior to initiation of a management plan or treatment for the disease * Patients must have initial imaging, laboratory and other clinical evaluations (see below) performed within 42 days prior to registration. Imaging reports, pathology reports and performance status will be collected * Patients must have beta-human chorionic gonadotropin (beta- HCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) assessments within 42 days prior to registration * NOTE: If the patient had an orchiectomy prior to registration, report tumor marker values before and after surgery on the Baseline Tumor Marker form * Patients must have risk of relapse assessment determined by the local investigator prior to registration * Patients must agree to submit required specimens for defined translational medicine studies. These specimens are drawn at the same time as standard laboratory evaluations (beta-HCG, AFP, and LDH); NOTE: Ideally, patients should be willing to return to their center performing surveillance (registering site) for the duration of the study to ensure that specimens are timed to standard clinical observations (the registering site's surveillance schedule) * Patients must be offered participation in specimen banking for future research. With patient's consent, specimens must be submitted. * Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
References
Publications (1)
- DERIVEDSeelemeyer F, Pfister D, Gossmann R, Steenbock O, Pappesch R, Merkelbach-Bruse S, Heidenreich A. Diagnostic performance of the microRNA-371a assay in small testicular masses: a real-world cohort study. BJU Int. 2026 May;137(5):914-919. doi: 10.1111/bju.70215. Epub 2026 Mar 13. PMID 41823372