Clinical trial · Observational
Safety and Feasibility of Reversible Induction Strategy
Safety and Feasibility of Reversible Induction Strategy Supported by HFNC Combined With Specific Anesthetic
NCT04434963CI-TRIAL-00053880unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Patients With Uncertain Difficult Airway | — | UNRESOLVED | — |
| Prostatic Cancer | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Successful rate of reversion
- timeFrame
- From the beginning of induction to 15min later
Secondary outcomes (4)
- measure
- TOFr 0.9 reversion time
- timeFrame
- From the beginning of induction to 15min later
- measure
- BIS 80 reversion time
- timeFrame
- From the beginning of induction to 15min later
- measure
- Tidal volume 6-8ml tidal volume 6-8ml/kg reversion time
- timeFrame
- From the beginning of induction to 15min later
- measure
- consciousness reversion time
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * \>18 years old,\<65 years old * Signed informed consent * Undergoing selective operation （ time of operation is over two hours） * ASA classification I-II * Mallampati classification 3-4 * suspicious difficult airway, but the anesthetists decide to try to rapid induction Exclusion Criteria: * Patients with several dysfunctions of liver, kidney or heart) * Patients with a full stomach or have other risk factors of reflux aspiration * Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant * Infection of the mouth or nose * Allergy history of any medicine which would be used in this study * Pregnant and lactating women * Patients with neuromuscular disease
References
Publications (0)
Data not yet available
No reference posted for this study.