Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Chest-wall and Breast Cancer

Inclusion Criteria:

* Age ≥ 18 years
* All biopsy-confirmed invasive ductal, invasive lobular and other rare histologic types of carcinoma
* Patients with early stage Breast cancer, or LABC ; i.e., Stage IIA - IIIC cancers (T2 N0 M0 to Any T, N3, M0) or Stage IV (Any T, Any N, M1) per AJCC guidelines (8th Edition)
* Assessed by a multidisciplinary team of treating medical, surgical and radiation oncologist and found suitable for the treatment
* Patient referred for palliative radiotherapy or standard radiotherapy, which may include any of the following dose regimens: 1) 20 Gy in 5 fractions, 2) 30 Gy in 10 fractions, 3) 40 Gy in 10 fractions, 4) 50 Gy in 20 fractions, 5) 60 Gy in 30 fractions and 6) 66 Gy in 33 fractions.
* Able to understand and give informed consent
* Weight \< 140 kg
* Target lesion accessible for MRg-FU+MB procedure
* Able to communicate sensation during the procedure
* Creatinine within normal institutional limits or creatinine clearance \>60 mL/min/1.73 m2 for patients with creatinine levels above institutional upper limit of normal.

Exclusion Criteria:

* Pregnant or lactating women may not participate due to the embryotoxic effects of protocol treatment. Women/ men of reproductive potential may not participate unless they have agreed to use an effective contraceptive method.
* Unable to have a contrast-enhanced MRI scan - standard of care criteria
* Patients on anthracycline or taxane based chemotherapy
* Patients with metallic or breast implants
* Subjects with inflammatory breast cancer, connective tissue disorder, musculoskeletal deformity
* Target lesion causing ulceration, bleeding or discharge of the overlying skin
* A fibrotic scar along the proposed FU beam path
* Severe cardiovascular, neurological, renal or hematological chronic disease
* Eastern Cooperative Oncology Group (ECOG) Performance Status ≥ 3
* Any condition in the investigator's opinion precludes participation
* Bleeding disorders/ High risk for deep vein thrombosis
* Unable to tolerate required stationary position during treatment
* Allergic to Definity microbubbles
* Cardiac disease or unstable hemodynamics including myocardial infarction within six months, unstable angina, congestive heart failure, ejection fraction \< 50%, cardiac shunts, cardiac arrythmia and cardiac pacemaker.
* Contraindication to perflutren including subjects with a family or personal history of QT prolongation or taking concomitant medications known to cause QTc prolongation like cisapride, erythromycin, tricyclic antidepressants, Class IA and III antiarrhythmic agents and some antipsychotics like haloperidol, droperidol, quetiapine, thioridazine, ziprasidone.
* QT prolongation observed on screening ECG (QTc \> 450ms for men or \>470ms for women)
* Severe hypertension (diastolic BP \> 100 mmHg)
* History of bleeding disorder, coagulopathy
* Severely impaired renal function with estimated glomerular filtration rate \< 30ml/min/1.73m2 and/or on dialysis