Clinical trial · Observational
Fibroids and Infertility - a Study of the Significance of Removal of Fibroids With Regard to Endometrial Receptivity
Mechanisms of Reduced Fertility in Women With Uterine Leiomyomas
NCT04426760CI-TRIAL-00045514FINunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We aim to explore some of the molecular factors that reduce fertility for women with leiomyomas, taking into account leiomyoma location, size, number and vascularity. Tissue samples from the endometrium and leiomyomas will be obtained during the mid secretory phase before and 3-6 months after surgical excision for a comprehensive search for key molecular derangements.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leiomyoma, Uterine | Uterine Corpus Leiomyoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Myomectomy per laparoscopy or laparotomy | Procedure | — | UNRESOLVED |
| Transcervical resection of fibroids | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Women with submucosal leiomyoma(s)
- description
- Women with submucosal leimyomas undergoing hysteroscopical removal of the leiomyoma
- interventionNames
- Procedure: Transcervical resection of fibroids
- label
- Women with intramural leiomyomas
- description
- Women with intramural leiomyomas undergoing myomectomy
- interventionNames
- Procedure: Myomectomy per laparoscopy or laparotomy
- label
- Infertility patients
- description
- Patients treated at the Department for Reproductive Medicine at the Oslo University hospital failing to conceive after 3 or more embryo transfers with good quality embryos.
- label
- Fertile women
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Age: 18 to 40 years * Presence of leiomyoma(s) * Regular menstrual cycle (28 +/- 7 days) * Having had at least 2 normal menstrual cycles after ending the treatment if previously treated with GnRH analogue * Signed informed consent Exclusion Criteria: * No treatment indication (no symptoms and/or no desire for fertility) * Contraindication for surgery * Known endometriosis * Known PCOS * Untreated hydrosalpinx * Malignancy; gynaecological or other location * Pre-malignant or malignant pap smear or endometrial biopsy * Hormonal treatment including ulipristal acetat and levonorgestrel intrauterine device last three months before inclusion in the study * Ongoing treatment with GnRH analogue * Pregnancy last 3 months * Ongoing lactation
References
Publications (0)
Data not yet available
No reference posted for this study.