Clinical trial · Observational
The Microbiome of Oesophageal Squamous Cell Carcinoma
NCT04425122CI-TRIAL-00063766unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective study on the microbiota associated with oesophageal squamous cell carcinoma (SCC). Patients with newly diagnosed SCC of oesophagus would be recruited for taking samples of oral and oesophageal rinse, tissue biopsies for investigation of the microbiota of oesophageal cancer. Control patients would be identified from patients scheduled for routine endoscopy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Microbial Colonization | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Upper endoscopy | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Esophageal cancer
- description
- Patients with esophageal cancer (SCC)
- interventionNames
- Diagnostic Test: Upper endoscopy
- label
- Non-cancer group
- description
- Non-cancer patients scheduled for upper endoscopy
- interventionNames
- Diagnostic Test: Upper endoscopy
Primary outcomes (1)
- measure
- Microbiological culture from biopsy specimens
- timeFrame
- 1month
- description
- Pattern of culture from specimens obtained, compared between cancer and non-cancer
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Cancer group: Inclusion criteria: 1. 18 Years and older 2. Able to provide informed consent 3. No cognitive impairment 4. Newly diagnosed OESCC or oesophageal dysplasia. Exclusion Criteria: 1\) On anticoagulation including Plavix, warfarin and NOAC's Control group: Inclusion Criteria: 1. Patients undergoing an OGD without a history of malignancy 2. 18 Years and older 3. Able to provide informed consent 4. No cognitive impairment Exclusion Criteria: 1\) On anticoagulation including Plavix, warfarin and NOAC's
References
Publications (0)
Data not yet available
No reference posted for this study.