Clinical trial · Interventional
The Diagnostic Ability of White Light Endoscopy and Magnifying Endoscopy With Optical Enhancement System
Evaluation of the Diagnostic Ability of White Light Endoscopy and Magnifying Endoscopy With Optical Enhancement System in Early Gastric Cancer and Intraepithelial Neoplasia: a Prospective Randomized Controlled Trial
NCT04411589CI-TRIAL-00047344unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to valuation of the diagnostic ability of white light imaging and magnifying endoscopy with optical enhancement system in early gastric cancer and intraepithelial neoplasia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Early Gastric Cancer | Early Gastric Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| magnifying endoscopy with optical enhancement system | Device | — | UNRESOLVED |
| white light endoscopy system | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Magnifying endoscopy with optical enhancement system group
- description
- Patients in this group go through gastroscopy under the magnifying endoscopy with optical enhancement system.
- interventionNames
- Device: magnifying endoscopy with optical enhancement system
- type
- ACTIVE_COMPARATOR
- label
- white light endoscopy group
- description
- Patients in this group go through gastroscopy under white light endoscopy.
- interventionNames
- Device: white light endoscopy system
Primary outcomes (1)
- measure
- detection rate of GIN and EGC
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 18-80 years with H. pylori infection or histologically verified gastric lesions (chronic atrophic gastritis, intestinal metaplasia, GIN or EGC) * Or patients aged 40-80 years from a region with high incidence of gastric cancer * Or patients aged 40-80 years with first-degree relative of patients with gastric cancer * Or patients aged 40-80 years with high-risk factors for gastric cancer (high salt or pickle diet or smoking or heavy drinking) Exclusion Criteria: * A history of gastrectomy * Active gastrointestinal bleeding or advanced gastric carcinoma * Coagulopathy or severe underlying diseases * Pregnancy or lactation * Absence of informed consent
References
Publications (1)
- DERIVEDWan M, Li GC, Ma MJ, Liu J, Li Z, Zuo XL, Li YQ. Optical enhancement with magnification versus white-light endoscopy for detecting gastric intestinal metaplasia and neoplasia: a randomized controlled trial. Gastrointest Endosc. 2025 Sep;102(3):337-344.e1. doi: 10.1016/j.gie.2025.02.015. Epub 2025 Feb 15. PMID 39956464