Monitoring Heart Rate Variability for the Early Detection of Pancreatic Cancer

Inclusion Criteria:

* Ability to understand and the willingness to sign an informed consent document
* Own a smartphone that uses Android or Apple iOS operating systems
* Participant must have one of the following:

  * Individuals with newly-diagnosed, treatment naive PDAC - all stages (applicable to Stage 1 only), or
  * Individuals with at least one of the following family phenotype and age will be included:

    * Two or more relatives with PDAC on the same side of the family, where 2 PDAC affected individuals are first-degree related (FDR) AND at least one PDAC-affected individual is an FDR of the subject; Age \>= 50 years OR 10 years before onset in family
    * Two affected FDR with PDAC; Age \>= 50 years OR 10 years before onset of an FDR
    * Any of BRCA1, BRCA2, PALB2, ATM mutations confirmed pathogenic or likely pathogenic; Age \>= 50 years OR 10 years before onset of an FDR or second-degree relative (SDR)
    * Familial atypical multiple mole-melanoma (FAMMM) with confirmed pathogenic or likely pathogenic mutation variants in: p16, CDKN2A; Age \>= 50 years
    * Known mutation carrier for STK11 (Peutz-Jeghers syndrome); Age \>= 50 years
    * Lynch syndrome (hereditary nonpolyposis colorectal cancer \[HNPCC\]) with confirmed pathogenic or likely pathogenic variants in: MLH1, MSH2, MSH6, PMS2, or EPCAM; Age \>= 50 years OR 10 years before onset of an FDR or SDR
    * Hereditary pancreatitis with confirmed PRSS1 pathogenic or likely pathogenic history of pancreatitis; Age \>= 50 years

Exclusion Criteria:

* Any medical conditions that in the opinion of the investigators would compromise participant safety and/or the integrity of the data