Clinical trial · Interventional
Perioperative Oral Nutrition Supplementation in Malnourished Surgical Cancer Patients
Perioperative Oral Nutrition Supplementation in Malnourished Surgical Cancer Patients- A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to evaluate the effectiveness of perioperative oral nutrition supplementation (ONS) on nutritional status in malnourished cancer patients undergoing elective surgery. The hypothesis is pre-operative ONS feeding in malnourished surgical cancer patients is effective on improving nutritional status. An extended period of 3 months post-operative ONS feeding is effective on improving nutritional status as compared to ONS feeding post-operatively during hospital stay only. Perioperative feeding is effective on improving secondary outcomes such as sleep quality, post-operative complications and length of hospital stay.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Colon | — | UNRESOLVED | — |
| Cancer of Breast | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ONS Pre-op + ONS Post-op | Dietary Supplement | — | UNRESOLVED |
| ONS Pre-op + ONS Post-op + ONS Post-op 3 months | Dietary Supplement | — | UNRESOLVED |
| Usual intake Pre-op + ONS Post-op | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- ONS Pre-op + ONS Post-op
- description
- Oral nutrition supplementation (ONS) pre-operatively and post-operatively up to being discharged from hospital
- interventionNames
- Dietary Supplement: ONS Pre-op + ONS Post-op
- type
- ACTIVE_COMPARATOR
- label
- ONS Pre-op + ONS Post-op + ONS Post-op 3 months
- description
- Oral nutrition supplementation (ONS) pre-operatively, post-operatively up to being discharged from hospital and an extended oral nutrition supplementation post-operatively up to 3 months
- interventionNames
- Dietary Supplement: ONS Pre-op + ONS Post-op + ONS Post-op 3 months
- type
- ACTIVE_COMPARATOR
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Male or female from all ethnicity * 25 to 65 years * BMI not less than 18.0 kg/m² * Cancer patients who are confirmed with elective surgery whose co-morbidities are stabilized based on the ASA Physical Status Classification System ASA Class 1 and 2 * Fulfil at least two characteristics of AND/ ASPEN Diagnosis of Malnutrition These characteristics are insufficient energy intake, weight loss, loss of muscle mass, loss of subcutaneous fat, localized or generalized fluid accumulation and diminished functional status as measured by handgrip strength. Exclusion Criteria: * Patients who require enteral or parenteral feeding * Pregnant or lactating * On chemotherapy or radiotherapy * Total gastrectomy or ileostomy * Metastasized cancer, upper gastrointestinal cancer, terminal diseases, decompensated liver or renal disease, major concurrent metabolic problem such as uncontrolled diabetes, dementia * On regular steroids prescription
References
Publications (1)
- DERIVEDWong TX, Chen ST, Ong SH, Shyam S, Kandasami P, Chee WSS. Study protocol for an open labelled randomised controlled trial of perioperative oral nutrition supplement in breast and colorectal cancer patients undergoing elective surgery. Trials. 2021 Nov 3;22(1):767. doi: 10.1186/s13063-021-05716-5. PMID 34732233