Clinical trial · Observational
Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort
Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: Prospective, Matched-randomized Observational Cohort Compatible With STROBE Guidelines
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In the present study, the severity of recurrent laryngeal nerve injury (RLNI) and hypocalcemia (H) will be followed-up and the probable interrelation between them will be proposed considering the clinical situation of patients, e.g. improvement in hypocalcemia also make a positive effect on voice? (any objective sign? Ca? PTH?), return of voice is parallel with the improvement in hypocalcemia? Postoperative calcium (Ca), parathyroid hormone (PTH), regular vocal cord evaluations by ear-nose-throat (ENT) exams, deterioration-stability-improvement of clinical symptoms regarding both Ca metabolism and vocal cord function will be noted at regular intervals (postoperative day 1-3-first, weekly control/first month, monthly/first 6-month, 3-monthly/6-12 months) at outpatient controls. Serum Ca, PTH, ENT evaluation of vocal cords-noted.
Conditions
Conditions (12)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Calcium Deficiency | — | UNRESOLVED | — |
| Iatrogenic Hypocalcemia | — | UNRESOLVED | — |
| Iatrogenic Hypoparathyroidism | — | UNRESOLVED | — |
| Multinodular Goiter | — | UNRESOLVED | — |
| PTH | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Thyroid Cancer, Papillary | Thyroid Gland Papillary Carcinoma | ALIAS | 0.90 |
| Thyroid Neoplasms | Thyroid Gland Neoplasm | ALIAS | 0.90 |
| Thyroid Nodule | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Total thyroidectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Control, s/p TT, without complication
- description
- Control (status/post-s/p total thyroidectomy-TT, without complication- demographics and BMI matched)
- interventionNames
- Procedure: Total thyroidectomy
- label
- Experimental, s/p TT with only VCP
- description
- Experimental (s/p TT, with only vocal cord paralysis-VCP, uni or bilateral)
- interventionNames
- Procedure: Total thyroidectomy
- label
- Experimental, s/p TT with only H
- description
- Experimental (s/p TT, with only hypocalcemia-H, transient or permanent)
- interventionNames
- Procedure: Total thyroidectomy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with total thyroidectomy indication, for either benign (e.g. multinodular goitre) or malign (e.g. thyroid carcinoma) thyroid disease * \>17 year-old * Available for close follow-ups at outpatient clinic * Available for close vocal cord exams Exclusion Criteria: * Patients with recurrent thyroid disease (benign/malign), prepared for a second operation * Preferance of thyroid surgery other than total thyroidectomy
References
Publications (2)
- RESULTCuschieri S. The STROBE guidelines. Saudi J Anaesth. 2019 Apr;13(Suppl 1):S31-S34. doi: 10.4103/sja.SJA_543_18. PMID 30930717
- RESULTGiulea C, Enciu O, Toma EA, Calu V, Miron A. The Tubercle of Zuckerkandl is Associated with Increased Rates of Transient Postoperative Hypocalcemia and Recurrent Laryngeal Nerve Palsy After Total Thyroidectomy. Chirurgia (Bucur). 2019 Sept-Oct;114(5):579-585. doi: 10.21614/chirurgia.114.5.579. PMID 31670633