Identification of New Diagnostic Protein Markers for Colorectal Cancer

The search for biochemical markers in patient's blood for non-invasive colorectal cancer diagnostic has not yielded satisfactory results to date. The search for blood in the stool by enzymatic techniques has certainly allowed the diminution of colorectal cancer mortality but its low sensitivity is still a disadvantage. The new immunological tests for search blood test in the stool are more sensitive and more specific but still insufficient. The originality of this project is based on the use of new technology developed in fundamental research based on the detection of circulating exosomes from tumor cells in the patient's serum. The detection of protein markers transported by tumor exosomes is original and innovative approach because it's still not considered in the literature. The use of innovative and non-invasive health technologies for the patient is an important factor in the care of patients in their health care journey. The non-invasive nature of the project could reduce the reticence of patients to participate in cancer screening. The results expected from the study can have a direct impact on the management of patients suspected of having colon cancer and thus make it possible to optimize the earliness of their diagnosis.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Immunoassay for stool positive blood test or family screening
* Patients seen in consultation for a colonoscopy
* Patient who gave their consent for the study (signed consent form)
* Patient affiliated to a health insurance plan

Exclusion Criteria:

* History of other cancers (except for cervical cancer or basal cell carcinoma treated for curative purposes)
* Patient under chemotherapy
* Patients with a known familial mutation (APC, MSI, MYH)
* Patients protected by law