Clinical trial · Observational
Image Guided RFA/MWA/CRYO of RCC Biomarker Profile Study
The Immune and Inflammatory Profile of Patients After Image Guided Ablation of Renal Cancer With Radiofrequency Ablation (RFA)/ Microwave Ablation (MWA) vs. Cryoablation (CRYO)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Often kidney cancer is diagnosed when the tumour is small and hasn't spread. Rather than major surgery to remove the whole kidney, image-guided ablation involving heat (microwave or radiofrequency) or freezing (cryotherapy) is often used to destroy the tumour using minimal invasive technique with much less risk and discomfort. Limited evidence suggests that ablation also activates the immune system which may help in fighting the cancer. We will investigate the immune and other changes by analysing blood samples from patients before and after ablation. Understanding this will help in designing more effective new treatments combining ablation with biological therapies.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Renal Cancer | Kidney Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Image Guided Ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Radiofrequency Ablation (RFA) of RCC
- description
- Patients following image guided radiofrequency ablation (RFA) of renal cell carcinoma (RCC)
- interventionNames
- Procedure: Image Guided Ablation
- label
- Microwave Ablation (MWA) of RCC
- description
- Patients following image guided microwave ablation (MWA) of renal cell carcinoma (RCC)
- interventionNames
- Procedure: Image Guided Ablation
- label
- Cryoablation (CRYO) of RCC
- description
- Patients following image guided cryoablation (CRYO) of renal cell carcinoma (RCC)
- interventionNames
- Procedure: Image Guided Ablation
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients underwent image guided ablation for renal cell carcinoma (RCC) with heat-based energy (RFA/MWA) or ice-based energy (CRYO) 2. No other prior treatment to RCC in either kidneys Exclusion Criteria: 1\. Patients with RCC that is not suitable for image guided ablation
References
Publications (0)
Data not yet available