Clinical trial · Interventional
MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy
Randomized Controlled Trial With a MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy - MOSAIC
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cystectomy is the chosen treatment of bladder cancer in 400 cases every year in DK. In replacement of the removed bladder, a urinary diversion is constructed using 15cm of terminal ilium (Ad Modum Bricker). Ureteral strictures are diagnosed in 15% of the cystectomized patients, and these patients are at increased risk of infections, loss of renal function and repeated interventions. The left ureter is diagnosed with 70% of all strictures, presumably due to the construction of the urinary diversion. A modified urinary diversion have been tested in two small studies. The modified diversion is prolonged with 5cm compared to the conventional urinary diversion. The prolongation permits the urinary diversion to reach both the left and the right side of the abdomen, resulting in greater resection of non-viably distal ureter and less mobilization of the left ureter, lowering the rates of strictures.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cystectomy and modified urinary conduit | Procedure | — | UNRESOLVED |
| Cystectomy and standard urinary conduit ad modum Bricker | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Control
- description
- Study subject will cohere to current national guidlines with a cystectomy and standard urinary conduit ad modum Bricker
- interventionNames
- Procedure: Cystectomy and standard urinary conduit ad modum Bricker
- type
- EXPERIMENTAL
- label
- Intervention
- description
- Subject in the interventional arm, will be treated with a cystectomy and modified retrosigmoid conduit
- interventionNames
- Procedure: Cystectomy and modified urinary conduit
Primary outcomes (1)
- measure
- Strictures
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Bladder cancer with the indication for robot assisted radical cystectomy * Ileal conduit ad modum Bricker as planned urinary diversion * Ability to understand the participant information orally and in writing * Signed consent form Exclusion Criteria: * Previous abdominal or pelvic radiotherapy * Previous major abdominal surgery involving resection of bowel or construction of an enteric stoma * Urostomy planned on the left side of the abdomen * Single kidney * Complete ureteral duplication (either uni- or bilaterally), known at time of inclusion * Pregnancy
References
Publications (0)
Data not yet available