Clinical trial · Interventional
Honey Products for Cancer Patients With Oral Mucositis: a Randomized Controlled Trial
Effects of Honey and Propolis on Head and Neck Cancer Patients With Oral Mucositis: a Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators plan to conduct a 3-year pioneering care research project for mucositis in cancer patients. These include: (1) an analysis of the incidence and severity of mucositis, severity, treatment methods, and treatment costs; (2) an RCT comparing the effectiveness of honey, Taiwan green propolis, and usual care in mucositis of cancer patients; (3) monitoring of related symptom changes using a smart bracelet device; (4) a measurement of IL-1, IL-6, IL-10, and TNF in saliva and (4) modeling of the trend of mucositis for alertness and search of essential parameters of the complications.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Mucositis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| honey | Dietary Supplement | — | UNRESOLVED |
| propolis | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- honey
- description
- Honey, 10 grams per pack, calories 33.4 calories, protein 0.05 grams, fat 0.07 grams, fructose + glucose 7.0 grams, sodium 0 mg. Usage is three times a day after three meals. After oral care is required before use, use 10 grams of longan honey, circulate in the oral cavity for at least 30 seconds, and slowly swallow. Do not eat, drink, or gargle within 30 minutes of use.
- interventionNames
- Dietary Supplement: honey
- type
- EXPERIMENTAL
- label
- propolis
- description
- Oil-soluble green propolis, propolis 100 mg / mL, dilute green propolis 200 times with edible oil, drink 0.5 mL each time, 3 times a day (a total of 50 mg). Usage: three times a day, after three meals. After oral care is required before use, draw about 0.5ml of green propolis into the mouth, circulate in the oral cavity for at least 30 seconds, and slowly swallow. Do not eat, drink or gargle within 30 minutes of use.
- interventionNames
- Dietary Supplement: propolis
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * age≧20 years old * diagnosed as head and neck cancer patients * Plan to Receive radiation therapy * Consciousness, ability to complete research assessment and willing to participate in research * Patients can be communicated in Mandarin and Taiwanese, and complete the questionnaire on their own or with the help of researchers. Exclusion Criteria: * History of allergic to honey, propolis, various pollen, alcohol * People with mental disorders or cognitive dysfunction * Diabetes mellitus * Critical of end of life patient
References
Publications (1)
- DERIVEDJen SC, Chen YW, Tsai JT, Kuo CC, Ting LL, Huang WY, Huang TW, Chen JH, Gautama MSN. Effects of honey and Taiwanese green propolis on oral mucositis and quality of life in head and neck cancer patients undergoing radiotherapy: a randomized controlled trial. Food Funct. 2025 Jun 16;16(12):4958-4969. doi: 10.1039/d5fo00067j. PMID 40424080