Clinical trial · Observational
Role of PET/MRI in Head and Neck Cancer
PET/CT and PET/MRI Based Treatment Modalities in the Modern Oncology
NCT04360993CI-TRIAL-00049175completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Neoplasm | Benign Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Malignant Neoplasm | Malignant Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients underwent PET/CT & PET/MRI
- description
- Patients with head and neck cancer were underwent PET/CT and PET/MRI for staging, assessment and follow up
- interventionNames
- Radiation: Radiotherapy
Primary outcomes (1)
- measure
- Difference in Apparent diffusion coefficient value between benign and malignant lesions
- timeFrame
- Baseline
- description
- Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 41 Years
- Maximum age
- 88 Years
Show eligibility criteria text
Inclusion Criteria: * Proved Head and neck cancer * Underwent PET/CT and PET/MRI * Lymph nodes due to primary Head and neck cancer. For healthy subject: * No previous history of malignancy. * no inflammation or infection in the neck region. * lymph node size \<10mm. Exclusion Criteria: * patients treated before by radiotherapy / chemoradiotherapy * patients underwent surgery * artifacts
References
Publications (2)
- DERIVEDFreihat O, Toth Z, Pinter T, Kedves A, Sipos D, Cselik Z, Lippai N, Repa I, Kovacs A. Pre-treatment PET/MRI based FDG and DWI imaging parameters for predicting HPV status and tumor response to chemoradiotherapy in primary oropharyngeal squamous cell carcinoma (OPSCC). Oral Oncol. 2021 May;116:105239. doi: 10.1016/j.oraloncology.2021.105239. Epub 2021 Feb 25. PMID 33640578
- DERIVEDFreihat O, Pinter T, Kedves A, Sipos D, Cselik Z, Repa I, Kovacs A. Diffusion-Weighted Imaging (DWI) derived from PET/MRI for lymph node assessment in patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Cancer Imaging. 2020 Aug 8;20(1):56. doi: 10.1186/s40644-020-00334-x. PMID 32771060