Clinical trial · Observational
Mu Opioid Receptor 1 Expression and Activation Patterns in Colorectal Cancer
Evaluation of the Difference in Expression of the Mu Type 1 Opioid Receptor and of the Markers of Its Activation (Cyclic Adenosine Monophosphate and Protein Kinase A) in Colorectal Cancer. Case-control Study in Patients With Tumor Recurrence Versus Disease-free Patients at 5 Years.
NCT04353882CI-TRIAL-00045162unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Surgery for Stage II / III Primary Colorectal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Assess the difference in MOR-1 expression between healthy and tumor tissue | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- patients with tumor recurrence
- interventionNames
- Other: Assess the difference in MOR-1 expression between healthy and tumor tissue
- label
- patients with-out tumor recurrence
- interventionNames
- Other: Assess the difference in MOR-1 expression between healthy and tumor tissue
Primary outcomes (1)
- measure
- MOR-1 expression by polymerase chain reaction (RT-qPCR) in tumor tissue and adjacent healthy tissue.
- timeFrame
- Day 1
Secondary outcomes (3)
- measure
- Cancer-free survival 5 years after surgery (disease-free survival-DFS).
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over 18 years of age. * Colorectal surgery scheduled between January 2010 - December 2014. * Stage II or III colon or rectum neoplasm (T3 / T4 N + M0). Exclusion Criteria: * Neoplasia of colon or rectum in Stage I or Stage IV. * Non-oncological colorectal surgery. * Urgent surgery
References
Publications (0)
Data not yet available
No reference posted for this study.