Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer

Inclusion Criteria:

1. No gender limitation, age 18-75 years old (including boundary value);
2. Late, metastatic, or recurrent malignant tumors that have received at least first-line standard treatment failure (progressive or intolerable disease, such as surgery, chemotherapy, radiotherapy, targeted therapy, etc.) or lack effective treatment, and the tumor CEA positive expression (tumor CEA positive or serum CEA level\> 50ng / ml confirmed by histology or pathology);
3. There are measurable and assessable lesions: the diameter of the lesion under CT or MRI scan is greater than 0.5cm;
4. The expected survival time is more than 12 weeks;
5. KPS≥60 ;
6. No serious mental disorders;
7. The functions of important organs are basically normal:

   1. Blood routine: white blood cells\> 2.0 × 10\^9 / L, neutrophils\> 0.8 × 10\^9 / L, lymphocytes\> 0.5 × 10\^9 / L, platelets\> 50 × 10\^9 / L, hemoglobin\> 90g / L;
   2. Cardiac function: cardiac ultrasound indicates that the cardiac ejection fraction is ≥50%, and there is no obvious abnormality on the electrocardiogram;
   3. Renal function: serum creatinine and urea nitrogen ≤3.0 × ULN;
   4. Liver function: ALT and AST ≤5.0 × ULN; total bilirubin ≤3.0 × ULN;
   5. Blood oxygen saturation\> 92%.
8. There are no other serious diseases that conflict with this plan (such as autoimmune diseases, immunodeficiency, organ transplantation);
9. There are no contraindications for apheresis or intravenous blood collection or other cell collection;
10. The patient or his guardian agrees to participate in this clinical trial and sign the ICF, indicating that he understands the purpose and procedures of this clinical trial and is willing to participate in the study.

Exclusion Criteria:

1. Have received CAR-T treatment or other genetically modified cell treatment before screening;
2. Participated in other clinical studies within 1 month before screening;
3. Received the following anti-tumor treatment before screening: received chemotherapy, targeted therapy or other experimental drug treatment within 4 weeks, except for those who have confirmed disease progression after treatment;
4. Have received live attenuated vaccine within 4 weeks before screening;
5. Cerebrovascular accident or seizure occurred within 6 months before signing the ICF;
6. Suffering from any of the following heart diseases:

   1. New York Heart Association (NYHA) stage III or IV congestive heart failure;
   2. Myocardial infarction occurred or received coronary artery bypass graft (CABG) ≤6 months before enrollment;
   3. Clinically significant ventricular arrhythmias, or history of syncope of unknown cause (except for conditions caused by vasovagal or dehydration);
   4. Severe cardiac insufficiency, severe heart valve disease and other cardiovascular system diseases;
7. There are active infections or uncontrollable infections requiring systemic treatment within 2 weeks before screening;
8. Active autoimmune diseases;
9. Suffering from chronic enteritis and / or intestinal obstruction;
10. Suffering from other malignant tumors, in addition to fully treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical resection, and ductal carcinoma in situ after radical resection;
11. Hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) positive and peripheral blood hepatitis B virus (HBV) DNA titer detection is greater than the normal range; hepatitis C virus (HCV) antibody positive and peripheral blood hepatitis C Virus (HCV) RNA test is greater than the normal range; human immunodeficiency virus (HIV) antibody positive; syphilis test positive;
12. Women who are pregnant or breastfeeding;
13. The situation that other researchers think is not suitable for participating in the study.