Clinical trial · Interventional
Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery
Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery Using Quantitative Analysis of Scintigraphy Results on Hybrid SPECT-CT Imaging
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory. The aim of this study was to evaluate if there is a beneficial effect of individualized timing of surgery using preoperative multi-phase 99mTc-MIBI single-photon emission computed tomography (SPECT)/CT on in-vivo characteristics of minimally invasive radio-guided parathyroidectomy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Parathyroid Adenoma | — | UNRESOLVED | — |
| Parathyroid Diseases | — | UNRESOLVED | — |
| Primary Hyperparathyroidism | — | UNRESOLVED | — |
| Thyroid Disease | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional (dual-phase) SPECT/CT | Procedure | — | UNRESOLVED |
| Conventional minimally-invasive radio-guided parathyroidectomy | Procedure | — | UNRESOLVED |
| Individualised minimally-invasive radio-guided parathyroidectomy | Procedure | — | UNRESOLVED |
| Multi-phase SPECT/CT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Conventional (dual-phase) SPECT/CT
- description
- Adult patients with primary hyperparathyroidism undergoing conventional (dual-phase) SPECT/CT (after 10 and 150 minutes) and conventional minimally-invasive radio-guided parathyroidectomy in a time span 2-3 hours from radionuclide administration.
- interventionNames
- Procedure: Conventional (dual-phase) SPECT/CT
- Procedure: Conventional minimally-invasive radio-guided parathyroidectomy
- type
- EXPERIMENTAL
- label
- Multi-phase SPECT/CT
- description
- Adult patients with primary hyperparathyroidism undergoing multi-phase SPECT/CT (after 10, 90, 150, 210 minutes) and individualized minimally-invasive radio-guided parathyroidectomy performed in a recommended time span based on standardized uptake value calculation.
- interventionNames
- Procedure: Multi-phase SPECT/CT
- Procedure: Individualised minimally-invasive radio-guided parathyroidectomy
Primary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients * No history of thyroid or parathyroid surgery * Diagnosis of primary hyperparathyroidism * Indication for 99mTc-MIBI SPECT/CT examination Exclusion Criteria: * Minor patients * Negative SPECT/CT findings * Patients refusing surgery * Previous combined surgery on the thyroid gland * Patients in high risk of general anesthesia * Patients who do not undergo surgery in the recommended time span
References
Publications (0)
Data not yet available